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Literature DB >> 529999

Lipid binding properties of a factor necessary for linoleic acid desaturation.

Abstract

Suspension and centrifugation of crude microsomes of rat liver in low ionic strength solution separated a soluble protein fraction that is necessary for the full activity of the linoleic acid desaturase. The fraction partially purified through Sephadex G-150 still retains lipids which are mainly constituted by phosphatidycholine. Linoleic acid predominates in the fatty acid composition. By NaCl gradient centrifugation and electrophoresis in gelatinized cellulose acetate, the factor behaves like a lipoprotein. The factor binds linoleic acid and linoleyl-CoA that are desaturated to gamma-linolenic acid when incubated with washed microsomes. Albumin does not replace the factor.

Entities: Chemical Species

Mesh：

Substances：

Year: 1979 PMID： 529999 DOI： 10.1007/BF02533440

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

15 in total

1. Separation of a protein factor necessary for the oxidative desaturation of fatty acids in the rat.

Authors: A Catalá; A M Nervi; R R Brenner
Journal: J Biol Chem Date: 1975-09-25 Impact factor: 5.157

2. Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids.

Authors: A KORNBERG; W E PRICER
Journal: J Biol Chem Date: 1953-09 Impact factor: 5.157

3. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

Authors: H G Enoch; A Catalá; P Strittmatter
Journal: J Biol Chem Date: 1976-08-25 Impact factor: 5.157

4. Evidence for the different responses of delta9-, delta6- and delta5-fatty acyl-CoA desaturases to cytoplasmic proteins.

Authors: R Jeffcoat; A P Dunton; A T James
Journal: Biochim Biophys Acta Date: 1978-01-27

10. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

Authors: R R Brenner; R O Peluffo
Journal: J Biol Chem Date: 1966-11-25 Impact factor: 5.157

5 in total

Lipid binding properties of a factor necessary for linoleic acid desaturation.

1. Separation of a protein factor necessary for the oxidative desaturation of fatty acids in the rat.

2. Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids.

3. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

4. Evidence for the different responses of delta9-, delta6- and delta5-fatty acyl-CoA desaturases to cytoplasmic proteins.

5. Purification and properties of rat liver microsomal stearyl coenzyme A desaturase.

6. A requirement for three protein components in microsomal stearyl coenzyme A desaturation.

7. Requirement for reduced diphosphopyridine nucleotide-cytochrome b5 reductase in stearly coenzyme A desaturation.

8. A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes.

9. A study of serum lipoproteins.

10. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

1. Fatty acid delta 5 desaturation in rat liver cell nuclei.

2. Recent studies of the enzymic synthesis of ricinoleic Acid by developing castor beans.

3. Microsomal Δ5 desaturation of eicosa-8,11,14-trienoic acid is activated by a cytosolic fraction.

4. Inhibition of arachidonate biosynthesis in hepatoma tissue culture cells by 11-deoxycorticosterone-induced factor.

5. Metabolism of fatty acids in rat brain microsomal membranes.