Literature DB >> 529026

Drug elimination interactions: analysis using a mathematical model.

R H Luecke, W D Wosilait.   

Abstract

A mathematical model was developed to analyze the elimination kinetics of drug interactions in the rat. The model is based on physiological blood flow rates and organ weights and includes Michaelis-Menten equations for enzymatic processes which are involved in the elimination of the drug; competitive inhibition interactions are computed for shared pathways. Using data from the single drugs, the model can simulate the results of experiments of the acute warfarin-BSP interactions in rats.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 529026     DOI： 10.1007/BF01061211

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  10 in total

1.  Extrahpetic distribution of sulfobromophthalein.

Authors:  C D Klaassen
Journal:  Can J Physiol Pharmacol       Date:  1975-02       Impact factor: 2.273

2.  Rapid equilibration of warfarin between rat tissue and plasma.

Authors:  T J Benya; J G Wagner
Journal:  J Pharmacokinet Biopharm       Date:  1975-08

3.  Computer simulation of sulfobromophthalein kinetics in the rat using flow-limited models with extrapolation to man.

Authors:  B Montandon; R J Roberts; L J Fischer
Journal:  J Pharmacokinet Biopharm       Date:  1975-08

4.  Warfarin-stereochemical aspects of its metabolism by rat liver microsomes.

Authors:  L R Pohl; S D Nelson; W R Porter; W F Trager; M J Fasco; F D Baker; J W Fenton
Journal:  Biochem Pharmacol       Date:  1976-10-01       Impact factor: 5.858

5.  Biliary excretion of bromsulphthalein and glutathione conjugate of bromsulphthalein in rats pretreated with diethyl maleate.

Authors:  F Varga; E Fischer; T S Szily
Journal:  Biochem Pharmacol       Date:  1974-09-15       Impact factor: 5.858

6.  Shared and separate pathways for biliary excretion of bilirubin and BSP in rats.

Authors:  R Clarenburg; C C Kao
Journal:  Am J Physiol       Date:  1973-07

7.  The relationship between the dose of warfarin, free drug in plasma, and its elimination in the bile of rats.

Authors:  W D Wosilait
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1973-11

8.  Methotrexate pharmacokinetics.

Authors:  K B Bischoff; R L Dedrick; D S Zaharko; J A Longstreth
Journal:  J Pharm Sci       Date:  1971-08       Impact factor: 3.534

9.  A program to simulate drug elimination interactions: warfarin and BSP - an illustrative example.

Authors:  R H Leucke; W D Wosilait
Journal:  Comput Programs Biomed       Date:  1978-03

10.  The effect of BSP and rifamycin on the excretion of warfarin in the bile of the rate.

Authors:  W D Wosilait
Journal:  Gen Pharmacol       Date:  1977
  10 in total
  3 in total

1.  Physiologically based pharmacokinetics of drug-drug interaction: a study of tolbutamide-sulfonamide interaction in rats.

Authors:  O Sugita; Y Sawada; Y Sugiyama; T Iga; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1982-06

2.  Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy man.

Authors:  A F Hofmann; G Molino; M Milanese; G Belforte
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

3.  A mechanistic modeling framework for predicting metabolic interactions in complex mixtures.

Authors:  Shu Cheng; Frederic Y Bois
Journal:  Environ Health Perspect       Date:  2011-08-11       Impact factor: 9.031
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.