A program to simulate drug elimination interactions: warfarin and BSP - an illustrative example.

The kinetics of drug elimination of interactive drug systems is stimulated by a set of differential equations based on mass balances, the mass of organs and blood flow rates. Experimentally determined concentration profiles of the drugs in the plasma and bile are used to evaluate clearance rate parameters. An example is shown in which the clearance of the anticoagulant warfarin is reduced to less than 50% of its normal rate due to the interference by BSP.