| Literature DB >> 5289582 |
P A Chervenick, L D Ellis, S F Pan, A L Lawson.
Abstract
Human leukemic cells with a marker (Philadelphia; Ph(1)) chromosome gave rise to granulocytic and mononuclear cell colonies when grown in vitro. All metaphases from a single colony were either Ph(1) positive or Ph(1) negative. No colonies contained a mixed cell population. This suggests that leukemic and normal cells exist simultaneously and that in vitro colonies are clonal in origin.Entities:
Mesh：
Year: 1971 PMID： 5289582 DOI： 10.1126/science.174.4014.1134
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728