Literature DB >> 13677271

Diagnostic and prognostic value of colony formation of hematopoietic progenitor cells in myeloid malignancies.

Leopold Ohler1, Klaus Geissler, Wolfgang Hinterberger.   

Abstract

Hematopoietic progenitor cells are capable of forming colonies of mature blood cells in semisolid media in response to specific growth factors. Colony assays have been extensively used for many years to study normal and malignant hematopoiesis in vitro. In fact, these assays have provided an excellent research tool for investigating growth and differentiation of progenitor cells in response to positive and negative regulators of hematopoiesis. However, apart from their role in basic research, colony assays are also widely used in routine clinical practice in the diagnosis of various hematologic disorders, such as aplastic anemia, myelodysplastic syndromes and myeloproliferative disorders. This review summarizes our current knowledge on the diagnostic value and prognostic significance of the growth of progenitor cells in peripheral blood and bone marrow in patients with myeloid malignancies.

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Year:  2003        PMID： 13677271     DOI： 10.1007/bf03041036

Source DB:  PubMed          Journal:  Wien Klin Wochenschr        ISSN： 0043-5325            Impact factor:   1.704


  121 in total

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Journal:  J Cell Physiol       Date:  1968-08       Impact factor: 6.384

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Journal:  Wien Klin Wochenschr       Date:  1999-08-20       Impact factor: 1.704

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Journal:  Br J Haematol       Date:  1998-10       Impact factor: 6.998

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Journal:  Leuk Lymphoma       Date:  1994-06

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Journal:  J Cell Physiol       Date:  1995-01       Impact factor: 6.384
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  5 in total

Review 1.  Pathogenesis, classification, and treatment of myelodysplastic syndromes (MDS).

Authors:  Peter Valent; Friedrich Wimazal; Ilse Schwarzinger; Wolfgang R Sperr; Klaus Geissler
Journal:  Wien Klin Wochenschr       Date:  2003-08-14       Impact factor: 1.704

2.  Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.

Authors:  Klaus Geissler; Eva Jäger; Agnes Barna; Michael Gurbisz; Temeida Graf; Elmir Graf; Thomas Nösslinger; Michael Pfeilstöcker; Heinz Tüchler; Thamer Sliwa; Felix Keil; Christoph Geissler; Sonja Heibl; Josef Thaler; Sigrid Machherndl-Spandl; Otto Zach; Ansgar Weltermann; Peter Bettelheim; Reinhard Stauder; Armin Zebisch; Heinz Sill; Ilse Schwarzinger; Bruno Schneeweiss; Leopold Öhler; Ernst Ulsperger; Rajko Kusec; Ulrich Germing; Wolfgang R Sperr; Paul Knöbl; Ulrich Jäger; Gregor Hörmann; Peter Valent
Journal:  Int J Mol Sci       Date:  2020-04-24       Impact factor: 5.923

3.  Multistep pathogenesis of chronic myelomonocytic leukemia in patients.

Authors:  Klaus Geissler; Eva Jäger; Agnes Barna; Michael Gurbisz; Renate Marschon; Temeida Graf; Thomas Nösslinger; Michael Pfeilstöcker; Sigrid Machherndl-Spandl; Reinhard Stauder; Armin Zebisch; Heinz Sill; Leopold Öhler; Rajko Kusec; Gregor Hoermann; Peter Valent
Journal:  Eur J Haematol       Date:  2022-03-23       Impact factor: 3.674

4.  Molecular Basis and Clinical Application of Growth-Factor-Independent In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia.

Authors:  Klaus Geissler; Eva Jäger; Agnes Barna; Michael Gurbisz; Temeida Graf; Elmir Graf; Thomas Nösslinger; Michael Pfeilstöcker; Sigrid Machherndl-Spandl; Reinhard Stauder; Armin Zebisch; Heinz Sill; Leopold Öhler; Rajko Kusec; Gregor Hörmann; Peter Valent
Journal:  Int J Mol Sci       Date:  2020-08-22       Impact factor: 5.923

5.  Myelomonocytic skewing in chronic myelomonocytic leukemia: phenotypic, molecular and biologic features and impact on survival.

Authors:  Klaus Geissler; Eva Jäger; Agnes Barna; Temeida Graf; Elmir Graf; Leopold Öhler; Gregor Hoermann; Peter Valent
Journal:  Eur J Haematol       Date:  2021-03-08       Impact factor: 2.997
  5 in total

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