Literature DB >> 5289364

Regulation of protein synthesis initiation in HeLa cells deprived of single essential amino acids.

M H Vaughan, P J Pawlowski, J Forchhammer.   

Abstract

In HeLa cells deprived of valine, histidine, or methionine initiation of protein synthesis decreases rapidly and disaggregation of polyribosomes also occurs. The mechanism of inhibition does not seem to involve the supply of RNA in the cell, and thus it differs from the initiation of inhibition at elevated temperatures. Polyribosomes rapidly form again if the missing amino acid is restored, even in the presence of actinomycin D.

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Year:  1971        PMID： 5289364      PMCID： PMC389350          DOI： 10.1073/pnas.68.9.2057

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM.

Authors:  M GIRARD; H LATHAM; S PENMAN; J E DARNELL
Journal:  J Mol Biol       Date:  1965-02       Impact factor: 5.469

2.  Regulation of protein synthesis in HeLa cells: translation at elevated temperatures.

Authors:  W McCormick; S Penman
Journal:  J Mol Biol       Date:  1969-01       Impact factor: 5.469

3.  Effects of valine deprivation on ribosome formation in HeLa cells.

Authors:  B E Maden; M H Vaughan; J R Warner; J E Darnell
Journal:  J Mol Biol       Date:  1969-10-28       Impact factor: 5.469

4.  Synthesis of ribosomal proteins in the absence of ribosome maturation in methionine-deficient HeLa cells.

Authors:  B E Maden; M H Vaughan
Journal:  J Mol Biol       Date:  1968-12       Impact factor: 5.469

5.  Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosis.

Authors:  H Fan; S Penman
Journal:  J Mol Biol       Date:  1970-06-28       Impact factor: 5.469

6.  Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution.

Authors:  B L Hogan; A Korner
Journal:  Biochim Biophys Acta       Date:  1968-11-20

7.  The effects of methionine deprivation on ribosome synthesis in HeLa cells.

Authors:  M H Vaughan; R Soeiro; J R Warner; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1967-10       Impact factor: 11.205

8.  Biosynthetic precursors of 30S and 50S ribosomal particles in Escherichia coli.

Authors:  G Mangiarotti; D Apirion; D Schlessinger; L Silengo
Journal:  Biochemistry       Date:  1968-01       Impact factor: 3.162

9.  Membrane-bound ribosomes in HeLa cells. I. Their proportion to total cell ribosomes and their association with messenger RNA.

Authors:  B Attardi; B Cravioto; G Attardi
Journal:  J Mol Biol       Date:  1969-08-28       Impact factor: 5.469

10.  Tryptophan deficiency in rabbit reticulocytes: polyribosomes during interrupted growth of hemoglobin chains.

Authors:  M Hori; J M Fisher; M Rabinovitz
Journal:  Science       Date:  1967-01-06       Impact factor: 47.728
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  17 in total

1.  Regulation of protein synthesis at the translational level in neuroblastoma cells.

Authors:  F Zucco; M Persico; A Felsani; S Metafora; G Augusti-Tocco
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

2.  Uptake of amino acids and thymidine during the first cell cycle of synchronized hamster cells.

Authors:  P M Bhargava; E P Allin; L Montagnier
Journal:  J Membr Biol       Date:  1975-02-17       Impact factor: 1.843

3.  Genome-wide identification and quantification of protein synthesis in cultured cells and whole tissues by puromycin-associated nascent chain proteomics (PUNCH-P).

Authors:  Ranen Aviner; Tamar Geiger; Orna Elroy-Stein
Journal:  Nat Protoc       Date:  2014-03-06       Impact factor: 13.491

4.  The mode of adrenocorticotrophin action in stimulating steroidogenesis: the obligatory role of adenosine 3':5'-cyclic monophosphate and the involvement of rapidly-turning-over protein.

Authors:  D Schulster; M C Richardson; C Mackie
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857

5.  Stimulation of polypeptide initiation in vitro after protein synthesis inhibition in vivo in HeLa cells.

Authors:  M Reichman; S Penman
Journal:  Proc Natl Acad Sci U S A       Date:  1973-09       Impact factor: 11.205

6.  Dietary protein intake and skeletal-muscle protein metabolism in rats. Studies with salt-washed ribosomes and transfer factors.

Authors:  S D Alexis; S Basta; V R Young
Journal:  Biochem J       Date:  1972-07       Impact factor: 3.857

7.  Essential role of optimal protein synthesis in preventing the apoptotic death of cultured B cell hybridomas.

Authors:  J Perreault; R Lemieux
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

8.  Protein initiation in eukaryotes: formation and function of a ternary complex composed of a partially purified ribosomal factor, methionyl transfer RNA, and guanosine triphosphate.

Authors:  D H Levin; D Kyner; G Acs
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

9.  Mechanism of action of the mycotoxin trichodermin, a 12,13-epoxytrichothecene.

Authors:  C M Wei; B S Hansen; M H Vaughan; C S McLaughlin
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

10.  A specific inhibitor of polypeptide-chain initiation in Escherichia coli.

Authors:  S Lee-Huang; H Lee; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205
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