Literature DB >> 5289241

Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity.

J A Dipaolo, P J Donovan, R L Nelson.   

Abstract

Treatment with either a flavone or benz(alpha)anthracene before the addition of a potent carcinogen, benzo(alpha)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(alpha)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(alpha)pyrene and 3-methylcholanthrene.

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Year:  1971        PMID： 5289241      PMCID： PMC389569          DOI： 10.1073/pnas.68.12.2958

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Inhibition of 9,10-dimethyl-1,2-benzanthracene skin carcinogenesis in mice by polycyclic hydrocarbons.

Authors:  W T HILL; D W STANGER; A PIZZO; B RIEGEL; P SHUBIK; W B WARTMAN
Journal:  Cancer Res       Date:  1951-11       Impact factor: 12.701

2.  An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene.

Authors:  J K Selkirk; E Huberman; C Heidelberger
Journal:  Biochem Biophys Res Commun       Date:  1971-06-04       Impact factor: 3.575

3.  Properties of Syrian hamster cells transformed in the presence of carcinogenic hydrocarbons.

Authors:  J A Dipaolo; P J Donovan
Journal:  Exp Cell Res       Date:  1967-11       Impact factor: 3.905

4.  Inhibition of the carcinogenic action of benzo(a)pyrene by flavones.

Authors:  L W Wattenberg; J L Leong
Journal:  Cancer Res       Date:  1970-07       Impact factor: 12.701

5.  In vitro transformation of hamster cells by polycyclic hydrocarbons: factors influencing the number of cells transformed.

Authors:  J A DiPaolo; P J Donovan; R L Nelson
Journal:  Nat New Biol       Date:  1971-04-21

6.  In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.

Authors:  Y Berwald; L Sachs
Journal:  J Natl Cancer Inst       Date:  1965-10       Impact factor: 13.506

7.  Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene.

Authors:  E Huberman; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1966-10       Impact factor: 11.205

8.  Radioautographic analysis of 7,12-dimethyl-benz(a)anthracene-3H incorporation and cell survival of Syrian hamster embryo cells during exposure to nucleic acid inhibitors.

Authors:  D I Connell; L A Riechers; J A DiPaolo
Journal:  J Natl Cancer Inst       Date:  1971-01       Impact factor: 13.506

9.  Alpha-naphthoflavone: an inhibitor of hydrocarbon cytotoxicity and microsomal hydroxylase.

Authors:  L Diamond; H V Gelboin
Journal:  Science       Date:  1969-11-21       Impact factor: 47.728

10.  In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.

Authors:  P L Grover; P Sims; E Huberman; H Marquardt; T Kuroki; C Heidelberger
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205
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  7 in total

1.  The effect of X-irradiation on hydrocarbon metabolism and on hydrocarbon-induced lethality and transformation in cells derived from mouse prostate.

Authors:  H Marquardt
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-12-06

2.  Effects of steroid hormones in fetal bovine serum on plating ang cloning of human cells in vitro.

Authors:  G E Milo; W B Malarkey; J E Powell; J R Blakeslee; D S Yohn
Journal:  In Vitro       Date:  1976-01

3.  Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.

Authors:  N Kinoshita; H V Gelboin
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

4.  Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.

Authors:  C J Harrison; J R Connell; T D Allen; C H Ockey
Journal:  Br J Cancer       Date:  1980-07       Impact factor: 7.640

5.  In vitro neoplastic transformation of Syrian hamster cells by lead acetate and its relevance to environmental carcinogenesis.

Authors:  J A Dipaolo; R L Nelson; B C Casto
Journal:  Br J Cancer       Date:  1978-09       Impact factor: 7.640

6.  Chromosome bands induced in human and Syrian hamster cells by chemical carcinogens.

Authors:  J A DiPaolo; N C Popescu
Journal:  Br J Cancer       Date:  1974-08       Impact factor: 7.640

7.  Two-stage carcinogenesis with rat embryo cells in tissue culture.

Authors:  C Lasne; A Gentil; I Chouroulinkov
Journal:  Br J Cancer       Date:  1977-06       Impact factor: 7.640
  7 in total

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