Literature DB >> 5288384

Structural basis of the A14 and A15 allotypic specificities in rabbit immunoglobulin G.

E Appella, A Chersi, R G Mage, S Dubiski.   

Abstract

The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the Cgamma2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the Cgamma2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human gamma chains is apparent (about 60-80%).

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Year:  1971        PMID： 5288384      PMCID： PMC389185          DOI： 10.1073/pnas.68.6.1341

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

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Authors:  C W TODD
Journal:  Biochem Biophys Res Commun       Date:  1963-05-03       Impact factor: 3.575

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Authors:  W KONIGSBERG; R J HILL
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3.  Immunochemistry and genetics of a "new" allotypic specificity Ae14 of rabbit gamma-G immunoglobulins: recombination in somatic cells.

Authors:  S Dubiski
Journal:  J Immunol       Date:  1969-07       Impact factor: 5.422

Review 4.  Somatic translocation of antibody genes.

Authors:  J A Gally; G M Edelman
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5.  Allotypy of rabbit immunoglobulin: an agglutinating specificity.

Authors:  W J Mandy; C W Todd
Journal:  Vox Sang       Date:  1968       Impact factor: 2.144

6.  [Heterogeneity of the immunoglobulins as revealed by their 3 kinds of antigenic specificity: isotypic, allotypic and idiotypic].

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Journal:  Bull Soc Chim Biol (Paris)       Date:  1968-09-28

7.  Genetics of immunoglobulin kappa-chains: chemical analysis of normal human light chains of differing Inv types.

Authors:  W D Terry; L E Hood; A G Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1969-05       Impact factor: 11.205

8.  Analysis of amino acid phenylthiohydantoins by gas chromatography.

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Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

9.  Genetic control of variable and constant regions of immunoglobulin heavy chains.

Authors:  R G Mage; G O Young-Cooper; C Alexander
Journal:  Nat New Biol       Date:  1971-03-10

10.  The molecular determinants of the A11 and A12 allotypic specificities in rabbit immunoglobulin.

Authors:  J W Prahl; W J Mandy; C W Todd
Journal:  Biochemistry       Date:  1969-12       Impact factor: 3.162
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  8 in total

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2.  Heavy chain genes of rabbit IgG: isolation of a cDNA encoding gamma heavy chain and identification of two genomic C gamma genes.

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Authors:  W van der Loo; C P Arthur; B J Richardson; M Wallage-Drees; R Hamers
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4.  Molecular cloning of rabbit gamma heavy chain mRNA.

Authors:  O Heidmann; F Rougeon
Journal:  Nucleic Acids Res       Date:  1982-03-11       Impact factor: 16.971

5.  Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype.

Authors:  K E Bernstein; C B Alexander; R G Mage
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

6.  Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran.

Authors:  B Clevinger; J Schilling; L Hood; J M Davie
Journal:  J Exp Med       Date:  1980-05-01       Impact factor: 14.307

7.  Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains.

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8.  Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.

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  8 in total

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