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Literature DB >> 5288361

Evidence for the existence of several molecular species in the "45S fraction" of mammalian ribosomal precursor RNA.

Abstract

Analysis of RNA (after 5 or 60 min of labeling with [(3)H]uridine) from L5178Y cells by electrophoresis in 1.7% polyacrylamide gels demonstrates that the ribosomal RNA "45S fraction" is not homogeneous but consists of at least three molecular species, conventionally designated 47S RNA, 46S RNA, and 45S RNA. Alternatives to the classical scheme for the biosynthesis of ribosomal RNA in mammalian cells are discussed.

Entities: Chemical Species

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Year: 1971 PMID： 5288361 PMCID： PMC389132 DOI： 10.1073/pnas.68.6.1117

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Amino acid metabolism in mammalian cell cultures.

Authors: H EAGLE
Journal: Science Date: 1959-08-21 Impact factor: 47.728

2. Processing of 45 s nucleolar RNA.

Authors: R A Weinberg; S Penman
Journal: J Mol Biol Date: 1970-01-28 Impact factor: 5.469

Review 3. Ribonucleic acids from animal cells.

Authors: J E Darnell
Journal: Bacteriol Rev Date: 1968-09

4. Relationship between HeLa cell ribosomal RNA and its precursors studied by high resolution RNA-DNA hybridization.

Authors: P Jeanteur; G Attardi
Journal: J Mol Biol Date: 1969-10-28 Impact factor: 5.469

5. Selective inhibition of ribosomal RNA synthesis in mammalian cells.

Authors: A Tavitian; S C Uretsky; G Acs
Journal: Biochim Biophys Acta Date: 1968-03-18

6. Effects of valine deprivation on the biosynthesis of ribosomal and messenger RNA in a mammalian cell line (L 5178 Y).

Authors: P Tiollais; F Galibert; M Boiron
Journal: Eur J Biochem Date: 1971-01-01

7. Methylation of 45 s ribosomal RNA precursor in HeLa cells.

Authors: E F Zimmerman; B W Holler
Journal: J Mol Biol Date: 1967-01-28 Impact factor: 5.469

8. Composition of nucleoli isolated from mammalian cells.

Authors: H Busch; R Desjardins; D Grogan; K Higashi; S T Jacob; M Muramatsu; T S Ro; W J Steele
Journal: Natl Cancer Inst Monogr Date: 1966-12

9. The regulation of RNA synthesis and processing in the nucleolus during inhibition of protein synthesis.

Authors: M Willems; M Penman; S Penman
Journal: J Cell Biol Date: 1969-04 Impact factor: 10.539

10. The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin.

Authors: M Siev; R Weinberg; S Penman
Journal: J Cell Biol Date: 1969-05 Impact factor: 10.539

13 in total

1. Intranuclear maturation pathways of rat liver ribosomal ribonucleic acids.

Authors: M D Dabeva; K P Dudov; A A Hadjiolov; I Emanuilov; B N Todorov
Journal: Biochem J Date: 1976-12-15 Impact factor: 3.857

2. Changes in ribosomal RNA processing paths in resting and phytohemagglutinin-stimulated guinea pig lymphocytes.

Authors: M J Purtell; D D Anthony
Journal: Proc Natl Acad Sci U S A Date: 1975-09 Impact factor: 11.205

3. Spacer sequences downstream of the 28S RNA coding region are part of the mouse rDNA transcription unit.

Authors: I Grummt; H Sorbaz; A Hofmann; E Roth
Journal: Nucleic Acids Res Date: 1985-04-11 Impact factor: 16.971

4. Morphology of nucleolar cistrons in a plant cell, Acetabularia mediterranea.

Authors: M F Trendelenburg; H Spring; U Scheer; W W Franke
Journal: Proc Natl Acad Sci U S A Date: 1974-09 Impact factor: 11.205

5. Differences in the primary structure of nucleolar and ribosomal high molecular weight RNA of the novikoff hepatoma and rat liver, and possible therapeutic implications.

Authors: S Seeber; H Busch
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1972