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Literature DB >> 5288252

Translation of exogenous messenger RNA for hemoglobin on reticulocyte and liver ribosomes.

P M Prichard, D J Picciano, D G Laycock, W F Anderson.

Abstract

The ribosome and initiation factor requirements for translation of rabbit-reticulocyte hemoglobin mRNA on rabbit reticulocyte ribosomes, reticulocyte ribosomal subunits, and liver ribosomes have been studied. Excellent synthesis of globin chains from exogenous mRNA in the fractionated cell-free system has been achieved. There is a near absolute requirement for each of the initiation factors, M(1), M(2), and M(3) (as well as for the supernatant proteins) for the translation of exogenous mRNA. Liver microsomal wash will partially replace reticulocyte factors M(1) and M(2), but will not replace the requirement for reticulocyte factor M(3). Rabbit liver ribosomes and rabbit reticulocyte ribosomes are equally active in their ability to support the translation of exogenous hemoglobin mRNA.

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Year: 1971 PMID： 5288252 PMCID： PMC389517 DOI： 10.1073/pnas.68.11.2752

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. The isolation of aribonucleic acid fraction from rabbit reticulocytes which enhances amino acid incorporation into protein.

Authors: J C Drach; J B Lingrel
Journal: Biochim Biophys Acta Date: 1966-08-17

2. Cell-free hemoglobin synthesis. II. Characteristics of the transfer ribonucleic acid-dependent assay system.

Authors: J M Gilbert; W F Anderson
Journal: J Biol Chem Date: 1970-05-10 Impact factor: 5.157

3. Synthesis of rabbit globin by a bacterial cell free system.

Authors: D G Laycock; J A Hunt
Journal: Nature Date: 1969-03-22 Impact factor: 49.962

4. Stimulation of globin synthesis by RNA purified from reticulocyte supernatant fraction.

Authors: L Grossbard; J Banks; P A Marks
Journal: Arch Biochem Biophys Date: 1968-05 Impact factor: 4.013

5. The ambiguities in the rabbit hemoglobin: evidence for a messenger RNA translated specifically into hemoglobin.

Authors: G Schapira; J C Dreyfus; N Maleknia
Journal: Biochem Biophys Res Commun Date: 1968-08-13 Impact factor: 3.575

6. Factors for the initiation of haemoglobin synthesis by rabbit reticulocyte ribosomes.

Authors: P M Prichard; J M Gilbert; D A Shafritz; W F Anderson
Journal: Nature Date: 1970-05-09 Impact factor: 49.962

7. Hemoglobin messenger ribonucleic acid. Synthesis of 9S and ribosomal ribonucleic acid during erythroid cell development.

Authors: M J Evans; J B Lingrel
Journal: Biochemistry Date: 1969-07 Impact factor: 3.162

8. The synthesis of mouse hemoglobin beta-chains in a rabbit reticulocyte cell-free system programmed with mouse reticulocyte 9S RNA.

Authors: R E Lockard; J B Lingrel
Journal: Biochem Biophys Res Commun Date: 1969-10-08 Impact factor: 3.575

9. [Activation of acellular hemoglobin synthesis by ribonucleic acid. IV. Action of ribonucleic acid fractions from liver nuclei obtained by sucrose gradient centrifugation].

Authors: J Kruh; J C Dreyfus; G Schapira
Journal: Biochim Biophys Acta Date: 1966-02-21

10. Stimulatory activity of high molecular weight ribonucleic acid in the rabbit reticulocyte cell-free system.

Authors: J A Hunt; B R Wilkinson
Journal: Biochemistry Date: 1967-06 Impact factor: 3.162

16 in total

1. In vitro translation of cardiovirus ribonucleic acid by mammalian cell-free extracts.

Authors: K L Eggen; A J Shatkin
Journal: J Virol Date: 1972-04 Impact factor: 5.103

2. Efficient translation of tobacco mosaic virus RNA and rabbit globin 9S RNA in a cell-free system from commercial wheat germ.

Authors: B E Roberts; B M Paterson
Journal: Proc Natl Acad Sci U S A Date: 1973-08 Impact factor: 11.205

3. A ribosome dissociation factor from rabbit reticulocytes distinct from initiation factor M3.

Authors: W C Merrick; N H Lubsen; W F Anderson
Journal: Proc Natl Acad Sci U S A Date: 1973-08 Impact factor: 11.205

4. Met-tRNAfMet binding to 40S ribosomal subunits: a site for the regulation of initiation of protein synthesis by hemin.

Authors: M J Clemens; E C Henshaw; H Rahamimoff; I M London
Journal: Proc Natl Acad Sci U S A Date: 1974-08 Impact factor: 11.205

5. Translation of reovirus messenger RNAs synthetesized in vitro into reovirus polypeptides by several mammalian cell-free extracts.

Authors: M J McDowell; W K Joklik; L Villa-Komaroff; H F Lodish
Journal: Proc Natl Acad Sci U S A Date: 1972-09 Impact factor: 11.205

6. Translational control of hemoglobin synthesis by an initiation factor required for recycling of ribosomes and for their binding to messenger RNA.

Authors: R Kaempfer; J Kaufman
Journal: Proc Natl Acad Sci U S A Date: 1972-11 Impact factor: 11.205

7. Formation of a mammalian initiation complex with reovirus messenger RNA, methionyl-tRNA F , and ribosomal subunits.

Authors: D H Levin; D Kyner; G Acs
Journal: Proc Natl Acad Sci U S A Date: 1972-05 Impact factor: 11.205

8. Calf crystallin synthesis in frog cells: the translation of lens-cell 14S RNA in oocytes.

Authors: A J Berns; M van Kraaikamp; H Bloemendal; C D Lane
Journal: Proc Natl Acad Sci U S A Date: 1972-06 Impact factor: 11.205

9. Initiation of hemoglobin synthesis: comparison of model reactions that use artificial templates with those using natural messenger RNA.

Authors: R G Crystal; W F Anderson
Journal: Proc Natl Acad Sci U S A Date: 1972-03 Impact factor: 11.205

10. The effects of hemin and double-stranded RNA on alpha and beta globin synthesis in reticulocyte and Krebs II ascites cell-free systems and the relationship of these effects to an initiation factor preparation.

Authors: Y Beuzard; I M London
Journal: Proc Natl Acad Sci U S A Date: 1974-07 Impact factor: 11.205