| Literature DB >> 5283954 |
Abstract
The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)(50) as a measure, the decreasing order of toxicity was TlCl(3) >/= In(NO(3))(3) > Ga(NO(3))(3) > Al(NO(3))(3). All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga(+3) and, to a lesser extent, In(+3) inhibited tumor growth. Ga(NO(3))(3) was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man.Entities:
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Year: 1971 PMID： 5283954 PMCID： PMC389254 DOI： 10.1073/pnas.68.7.1623
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205