Literature DB >> 527878

Virus isolation studies in Crohn's disease: a negative report.

R J Phillpotts, J Hermon-Taylor, B N Brooke.   

Abstract

Homogenates of gut and mesenteric lymph node tissue from patients with Crohn's disease, ulcerative colitis, and control patients were tested for cytopathic effect (CPE) production in a series of cell lines including rabbit ileal and W138 cells. A CPE was produced in W138 cells by tissue homogenates from patients with Crohn's disease, ulcerative colitis, and control patients. Evidence was obtained to suggest that this effect, although superficially similar to a viral CPE, was due to toxic protein constituents of inflamed tissue homogenate.

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Year:  1979        PMID： 527878      PMCID： PMC1412821          DOI： 10.1136/gut.20.12.1057

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  9 in total

1.  Isolation and characterization of a viral agent from intestinal tissue of patients with Crohn's disease and other intestinal disorders.

Authors:  M D Aronson; C A Phillips; W L Beeken; B R Forsyth
Journal:  Prog Med Virol       Date:  1975

2.  FACTORS IN THE AETIOLOGY OF REGIONAL ENTERITIS.

Authors:  J KYLE; T M BELL; I B PORTEOUS; D W BLAIR
Journal:  Bull Soc Int Chir       Date:  1963 Nov-Dec

3.  Studies on the viral etiology of regional enteritis and ulcerative colitis: a negative report.

Authors:  S S SCHNEIERSON; J H GARLOCK; B SHORE; W D STUART; M STEINGLASS; B ARONSON
Journal:  Am J Dig Dis       Date:  1962-09

4.  Viral investigations in ulcerative colitis and regional enteritis.

Authors:  G W Farmer; M M Vincent; D A Fuccillo; L Horta-Barbosa; S Ritman; J L Sever; G L Gitnick
Journal:  Gastroenterology       Date:  1973-07       Impact factor: 22.682

5.  Further electron microscopic evidence of virus-like particles in Crohn's disease.

Authors:  J F Riemann
Journal:  Acta Hepatogastroenterol (Stuttg)       Date:  1977-04

6.  Isolation of reovirus-like agents from patients with Crohn's disease.

Authors:  P J Whorwell; C A Phillips; W L Beeken; P K Little; K D Roessner
Journal:  Lancet       Date:  1977-06-04       Impact factor: 79.321

7.  Electron microscopic studies of viral agents in Crohn's disease.

Authors:  G L Gitnick; V J Rosen
Journal:  Lancet       Date:  1976-07-31       Impact factor: 79.321

8.  The gel-filtration behaviour of proteins related to their molecular weights over a wide range.

Authors:  P Andrews
Journal:  Biochem J       Date:  1965-09       Impact factor: 3.857

9.  Cultivation of viral agents from Crohn's disease. A new sensitive system.

Authors:  G L Gitnick; M H Arthur; I Shibata
Journal:  Lancet       Date:  1976-07-31       Impact factor: 79.321
  9 in total
  12 in total

1.  Immunoprecipitation of antigen-associated [32P]-labelled nucleic acids from Crohn's disease mesenteric lymph nodes.

Authors:  P D Butcher; J J McFadden; A M Murray; J Hermon-Taylor
Journal:  Br J Exp Pathol       Date:  1985-12

2.  The electrophoretic analysis of low molecular weight nucleic acids from Crohn's disease tissues in the search for an unconventional small infectious agent. Brief report.

Authors:  P D Butcher; J J McFadden; J Hermon-Taylor
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

3.  Hybridomas using athymic nude mouse injected with Crohn's disease (CD) tissue filtrate. Immunoreactivity of the hybridomas with CD sera.

Authors:  K M Das; M Vecchi; A Novikoff; S Mazumdar; P M Novikoff
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307

4.  Isolation of intestinal mononuclear cells: factors released which affect lymphocyte viability and function.

Authors:  P R Gibson; A Hermanowicz; H J Verhaar; D J Ferguson; A L Bernal; D P Jewell
Journal:  Gut       Date:  1985-01       Impact factor: 23.059

5.  Immunity to cytopathic agents associated with Crohn's disease: a negative study.

Authors:  M Chiba; L C McLaren; R G Strickland
Journal:  Gut       Date:  1982-04       Impact factor: 23.059

Review 6.  Progress and frustration in inflammatory bowel disease.

Authors:  B N Brooke
Journal:  Ann R Coll Surg Engl       Date:  1980-11       Impact factor: 1.891

7.  Cytopathic effects in cultures inoculated with material from Crohn's disease.

Authors:  C O Moráin; H Prestage; P Harrison; A J Levi; D A Tyrrell
Journal:  Gut       Date:  1981-10       Impact factor: 23.059

8.  Search for evidence of a viral aetiology for inflammatory bowel disease.

Authors:  H H Yoshimura; M K Estes; D Y Graham
Journal:  Gut       Date:  1984-04       Impact factor: 23.059

9.  Detection and partial characterization of Crohn's disease tissue specific proteins recognized by Crohn's disease sera.

Authors:  S Bagchi; K M Das
Journal:  Clin Exp Immunol       Date:  1984-01       Impact factor: 4.330

Review 10.  Crohn's disease and the mycobacterioses: a review and comparison of two disease entities.

Authors:  R J Chiodini
Journal:  Clin Microbiol Rev       Date:  1989-01       Impact factor: 26.132
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