Literature DB >> 5277098

Transformation of rat and hamster embryo cells by extracts of city smog.

A E Freeman, P J Price, R J Bryan, R J Gordon, R V Gilden, G J Kelloff, R J Huebner.   

Abstract

Extracts of particulate matter from condensates of city air were tested for their ability to transform rat or hamster cell cultures. Uninfected rat embryo cultures were not transformed, but cultures chronically infected with Rauscher leukemia virus were transformed by benzpyrene or by extracts of city smog. The smog extracts were 600 times more active than pure benzpyrene as transforming agents. Hamster embryo cultures infected with hamster leukemia virus were equally as sensitive as leukemia-infected rat cultures to the transforming effects of smog; uninfected hamster cultures were also transformed, although tenfold higher doses of smog extract were required.

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Year:  1971        PMID： 5277098      PMCID： PMC388957          DOI： 10.1073/pnas.68.2.445

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Morphological transformation of rat embryo cells induced by diethylnitrosamine and murine leukemia viruses.

Authors:  A E Freeman; P J Price; H J Igel; J C Young; J M Maryak; R J Huebner
Journal:  J Natl Cancer Inst       Date:  1970-01       Impact factor: 13.506

2.  Morphological conversion, hyperconversion and reversion of mammalian cells treated in vitro with N-nitrosomethylurea.

Authors:  F K Sanders; B O Burford
Journal:  Nature       Date:  1968-11-02       Impact factor: 49.962

3.  Malignant conversion of cells in vitro by carcinogens and viruses.

Authors:  E Borenfreund; M Krim; F K Sanders; S S Sternberg; A Bendich
Journal:  Proc Natl Acad Sci U S A       Date:  1966-08       Impact factor: 11.205

4.  Carcinogenesis in tissue culture. IX. Malignant transformation of cultured rat cells treated with 4-nitroquinoline-1-oxide.

Authors:  M Namba; H Masuji; J Sato
Journal:  Jpn J Exp Med       Date:  1969-06

5.  Transformation and neoplastic development in vitro of hamster embryonic cells by 4-nitroquinoline-1-oxide and its derivatives.

Authors:  T Kuroki; H Sato
Journal:  J Natl Cancer Inst       Date:  1968-07       Impact factor: 13.506

6.  In vitro malignant transformation of cells derid from mouse prostate in the presence of 3-methylcholanthrene.

Authors:  T T Chen; C Heidelberger
Journal:  J Natl Cancer Inst       Date:  1969-06       Impact factor: 13.506

7.  In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.

Authors:  Y Berwald; L Sachs
Journal:  J Natl Cancer Inst       Date:  1965-10       Impact factor: 13.506

8.  The in vitro induction of an increase in cell multiplication and cellular life span by the water-soluble carcinogen dimethylnitrosamine.

Authors:  E Huberman; S Salzberg; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1968-01       Impact factor: 11.205

9.  Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture.

Authors:  J W Hartley; W P Rowe; W I Capps; R J Huebner
Journal:  J Virol       Date:  1969-02       Impact factor: 5.103

10.  Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus.

Authors:  G Kelloff; R J Huebner; Y K Lee; R Toni; R Gilden
Journal:  Proc Natl Acad Sci U S A       Date:  1970-02       Impact factor: 11.205
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  6 in total

1.  Molecular characteristics of some carcinogenic hydrocarbons.

Authors:  E Cavalieri; M Calvin
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

2.  I. In vitrol transformation of rat embryo cells: correlations with the known tumorigenic activities of chemicals in rodents.

Authors:  A E Freeman; H J Igel; P J Price
Journal:  In Vitro       Date:  1975 Mar-Apr

3.  5-Bromo-2'-deoxyuridine potentiation of transformation of rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells.

Authors:  A E Freeman; R V Gilden; M L Vernon; R G Wolford; P E Hugunin; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

4.  Activation and isolation of hamster-specific C-type RNA viruses from tumors induced by cell cultures transformed by chemical carcinogens.

Authors:  A E Freeman; G J Kelloff; R V Gilden; W T Lane; A P Swain; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205

Review 5.  Formation and fate of gaseous and particulate mutagens and carcinogens in real and simulated atmospheres.

Authors:  J N Pitts
Journal:  Environ Health Perspect       Date:  1983-01       Impact factor: 9.031

6.  The histological appearance of tumours derived from rat embryo cells transformed in vitro spontaneously and after treatment with nitrosomethylurea.

Authors:  D J Kirkland; C R Pick
Journal:  Br J Cancer       Date:  1973-11       Impact factor: 7.640
  6 in total

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