Literature DB >> 5275385

Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin.

S Penman, M Rosbash, M Penman.   

Abstract

Cordycepin (3'-deoxyadenosine) suppresses the labeling of messenger RNA in HeLa cells. The drug has no effect on either the labeling of nuclear heterogeneous RNA or on the transport of messenger RNA into the cytoplasm. The results suggest that messenger RNA and nuclear heterogeneous RNA are synthesized separately, and that the transcription of messenger RNA is inhibited by the drug.

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Year:  1970        PMID： 5275385      PMCID： PMC283442          DOI： 10.1073/pnas.67.4.1878

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Polyphosphate groups at the 5'-ends of nuclear dRNA fractions.

Authors:  A P. Ryskov; G P. Georgiev
Journal:  FEBS Lett       Date:  1970-06-08       Impact factor: 4.124

2.  Amino acid metabolism in mammalian cell cultures.

Authors:  H EAGLE
Journal:  Science       Date:  1959-08-21       Impact factor: 47.728

3.  Selective inhibition of the synthesis of mitochondria-associated RNA by ethidium bromide.

Authors:  E Zylber; C Vesco; S Penman
Journal:  J Mol Biol       Date:  1969-08-28       Impact factor: 5.469

4.  Patterns of RNA metabolism in a differentiated cell: a rapidly labeled, unstable 60S RNA with messenger properties in duck erythroblasts.

Authors:  K Scherrer; L Marcaud; F Zajdela; I M London; F Gros
Journal:  Proc Natl Acad Sci U S A       Date:  1966-11       Impact factor: 11.205

5.  Messenger RNA-protein complexes and newly synthesized ribosomal subunits: analysis of free particles and components of polyribosomes.

Authors:  R P Perry; D E Kelley
Journal:  J Mol Biol       Date:  1968-07-14       Impact factor: 5.469

6.  Ribosomal RNA synthesis and processing in a particulate site in the HeLa cell nucleus.

Authors:  S Penman; I Smith; E Holtzman
Journal:  Science       Date:  1966-11-11       Impact factor: 47.728

7.  Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes.

Authors:  G Attardi; H Parnas; M I Hwang; B Attardi
Journal:  J Mol Biol       Date:  1966-09       Impact factor: 5.469

8.  Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA.

Authors:  J R Warner; R Soeiro; H C Birnboim; M Girard; J E Darnell
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

9.  Use of low concentrations of actinomycin D in the study of RNA synthesis in Ehrlich ascites cells.

Authors:  W K Roberts; J F Newman
Journal:  J Mol Biol       Date:  1966-09       Impact factor: 5.469

10.  The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin.

Authors:  M Siev; R Weinberg; S Penman
Journal:  J Cell Biol       Date:  1969-05       Impact factor: 10.539
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  71 in total

1.  Effect of cordycepin on the replication of western equine encephalitis virus.

Authors:  K Hashimoto; B Simizu
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

2.  Induction of N-acetylglucosamine-catabolic pathway in spheroplasts of Candida albicans.

Authors:  B Singh; A Datta
Journal:  Biochem J       Date:  1979-02-15       Impact factor: 3.857

3.  Very short-lived and stable mRNAs from resting human lymphocytes.

Authors:  S L Berger; H L Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

4.  Effect of cordycepin triphosphate on in vitro RNA synthesis by plant viral replicases.

Authors:  J L White; W O Dawson
Journal:  J Virol       Date:  1979-02       Impact factor: 5.103

5.  The sensitivity of RNA polymerases I and II from Novikoff hepatoma (N1S1) cells to 3'-deoxyadenosine 5'-triphosphate.

Authors:  R C Desrosiers; F M Rottman; J A Boezi; H C Towle
Journal:  Nucleic Acids Res       Date:  1976-02       Impact factor: 16.971

6.  Three mRNA populations differing in turnover and processing in mouse liver.

Authors:  E V Lubimova; T V Chernovskaja; M I Lerman
Journal:  Mol Biol Rep       Date:  1975-12       Impact factor: 2.316

7.  Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm.

Authors:  Joan C Ritland Politz; Richard A Tuft; Kannanganattu V Prasanth; Nina Baudendistel; Kevin E Fogarty; Larry M Lifshitz; Jörg Langowski; David L Spector; Thoru Pederson
Journal:  Mol Biol Cell       Date:  2005-12-21       Impact factor: 4.138

8.  Early Actions of Gibberellic Acid on the Embryo and on the Endosperm of Avena fatua Seeds.

Authors:  S S Chen; W M Park
Journal:  Plant Physiol       Date:  1973-08       Impact factor: 8.340

9.  Rapid Inhibition of Auxin-induced Elongation of Avena Coleoptile Segments by Cordycepin.

Authors:  M G Cline; M M Rehm
Journal:  Plant Physiol       Date:  1974-08       Impact factor: 8.340

10.  Evidence for post-transcriptional regulation by insulin of 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol synthesis in human mononuclear leucocytes.

Authors:  W Krone; H Greten
Journal:  Diabetologia       Date:  1984-05       Impact factor: 10.122
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