Literature DB >> 16789174

Effect of cordycepin triphosphate on in vitro RNA synthesis by plant viral replicases.

J L White1, W O Dawson.   

Abstract

In vitro RNA synthesis by tobacco mosaic virus and cowpea chlorotic mottle virus replicase were inhibited by cordycepin triphosphate. Inhibition could be overcome with higher concentrations of ATP in assay mixtures but not with UTP. Products synthesized in vitro by tobacco mosaic virus RNA replicase in the presence of inhibitor revealed replicative form but not replicative intermediate RNAs. These results suggest that cordycepin triphosphate competes specifically with ATP and results in premature termination of viral RNA synthesis in vitro.

Entities:  

Year:  1979        PMID： 16789174      PMCID： PMC353220     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

1.  Effect of cordycepin (3'-deoxyadenosine) on virus-specific RNA species synthesized in Newcastle disease virus-infected cells.

Authors:  S R Weiss; M A Bratt
Journal:  J Virol       Date:  1975-12       Impact factor: 5.103

2.  Synthesis of tobacco mosaic virus in intact tobacco leaves systemically inoculated by differential temperature treatment.

Authors:  W O Dawson; D E Schlegel; M C Lung
Journal:  Virology       Date:  1975-06       Impact factor: 3.616

3.  THE EFFECTS OF 3'-DEOXYADENOSINE ON THE SYNTHESIS OF RIBONUCLEIC ACID.

Authors:  H T SHIGEURA; C N GORDON
Journal:  J Biol Chem       Date:  1965-02       Impact factor: 5.157

4.  Effects of cordycepin and cordycepintriphosphate on polyadenylic and ribonucleic acid-synthesising enzymes from eukaryotes.

Authors:  G Maale; G Stein; R Mans
Journal:  Nature       Date:  1975-05-01       Impact factor: 49.962

5.  Poly (A) sequences of vaccinia virus messenger RNA: nature, mode of addition and function during translation in vitra and in vivo.

Authors:  J R Nevins; W K Joklik
Journal:  Virology       Date:  1975-01       Impact factor: 3.616

Review 6.  Characteristics and significance of the polyadenylate sequence in mammalian messenger RNA.

Authors:  G Brawerman
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1976

7.  Replication of tobacco mosaic virus. II. The in vitro synthesis of high molecular weight virus-specific RNAs.

Authors:  D W Bradley; M Zaitlin
Journal:  Virology       Date:  1971-07       Impact factor: 3.616

8.  In vitro replication of tobacco mosaic virus RNA in tobacco callus cultures: solubilization of membrane-bound replicase and partial purification.

Authors:  J L White; H H Murakishi
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103

9.  Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin.

Authors:  S Penman; M Rosbash; M Penman
Journal:  Proc Natl Acad Sci U S A       Date:  1970-12       Impact factor: 11.205

10.  Polyadenylation of vesicular stomatitis virus mRNA.

Authors:  E Ehrenfeld
Journal:  J Virol       Date:  1974-05       Impact factor: 5.103
View more
  5 in total

1.  Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants.

Authors:  Hyung Suk Oh; Harsh B Pathak; Ian G Goodfellow; Jamie J Arnold; Craig E Cameron
Journal:  J Virol       Date:  2009-07-08       Impact factor: 5.103

2.  Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication.

Authors:  Eunhyun Ryu; Myoungki Son; Minjung Lee; Kanghyo Lee; Jae Youl Cho; Sungchan Cho; Suk Kyeong Lee; You Mie Lee; Hyosun Cho; Gi-Ho Sung; Hyojeung Kang
Journal:  Oncoscience       Date:  2014-12-18

3.  Potent Inhibitory Activities of the Adenosine Analogue Cordycepin on SARS-CoV-2 Replication.

Authors:  Amgad M Rabie
Journal:  ACS Omega       Date:  2022-01-11

Review 4.  Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris.

Authors:  Li Wang; Huanhuan Yan; Bin Zeng; Zhihong Hu
Journal:  Bioengineering (Basel)       Date:  2022-02-11

5.  Cryptoporus volvatus extract inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro and in vivo.

Authors:  Li Gao; Weiwei Zhang; Yipeng Sun; Qian Yang; Jie Ren; Jinhua Liu; Hexiang Wang; Wen-Hai Feng
Journal:  PLoS One       Date:  2013-05-21       Impact factor: 3.240
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.