Literature DB >> 526706

Naloxone inhibits the anti-diarrhoeal activity of loperamide.

M F Piercey, M J Ruwart.   

Abstract

1 Subcutaneous prostaglandin E2 (2.5 mg/kg) produces profuse diarrhoea in fed rats. 2 Pretreatment of rats with subcutaneous loperamide (1.0 mg/kg) completely prevents prostaglandin-induced diarrhoea. If naloxone is administered prior to loperamide injections the activity of the antidiarrhoeal compound is completely destroyed. 3 These data provide strong evidence that the antidiarrhoeal activity of loperamide is mediated via the opiate receptor.

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Year:  1979        PMID： 526706      PMCID： PMC2043689          DOI： 10.1111/j.1476-5381.1979.tb10840.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Investigations on drug produced and subjectively experienced discriminative stimuli. 2. Loperamide, an antidiarrheal devoid of narcotic cue producing actions.

Authors:  F C Colpaert; C J Niemegeers; H Lal; P A Janssen
Journal:  Life Sci       Date:  1975-03-01       Impact factor: 5.037

2.  Interaction of loperamide with [3H]naloxone binding sites in guinea pig brain and myenteric plexus.

Authors:  G A Clay; C R Mackerer; T K Lin
Journal:  Mol Pharmacol       Date:  1977-05       Impact factor: 4.436

3.  Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs.

Authors:  K D Stahl; W van Bever; P Janssen; E J Simon
Journal:  Eur J Pharmacol       Date:  1977-12-01       Impact factor: 4.432

4.  Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues.

Authors:  J M Van Nueten; P A Janssen; J Fontaine
Journal:  Arzneimittelforschung       Date:  1974-10

5.  Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.

Authors:  C J Niemegeers; F M Lenaerts; P A Janssen
Journal:  Arzneimittelforschung       Date:  1974-10

6.  On the antidiarrhoeal and analgesic properties of diphenoxylate, difenoxine and loperamide in mice and rats.

Authors:  C Bianchi; A Goi
Journal:  Arzneimittelforschung       Date:  1977

7.  Loperamide binding to opiate receptor sites of brain and myenteric plexus.

Authors:  C R Mackerer; G A Clay; E Z Dajani
Journal:  J Pharmacol Exp Ther       Date:  1976-10       Impact factor: 4.030

8.  The pharmacology of SC-27166: a novel antidiarrheal agent.

Authors:  E Z Dajani; R G Bianchi; P F East; J L Bloss; G W Adelstein; C H Yen
Journal:  J Pharmacol Exp Ther       Date:  1977-12       Impact factor: 4.030

9.  Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study.

Authors:  A P Lange; N J Secher; W Amery
Journal:  Acta Med Scand       Date:  1977

10.  The effect of loperamide on prostaglandin induced diarrhoea in rat and man.

Authors:  S M Karim; P G Adaikan
Journal:  Prostaglandins       Date:  1977-02
  10 in total
  13 in total

1.  Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum.

Authors:  K J Moriarty; D D Rolston; M J Kelly; M Shield; M L Clark
Journal:  Gut       Date:  1985-01       Impact factor: 23.059

2.  Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide.

Authors:  E B Chang; D R Brown; N S Wang; M Field
Journal:  J Clin Invest       Date:  1986-07       Impact factor: 14.808

3.  Stimulation of gastrointestinal motility by loperamide in dogs.

Authors:  J Fioramonti; M J Fargeas; L Bueno
Journal:  Dig Dis Sci       Date:  1987-06       Impact factor: 3.199

4.  Subcutaneous loperamide prevents gastric lesions induced by necrotizing agents in rats.

Authors:  Y Hatakeyama; M Tomoi; M Ohtsuka; K Shimomura
Journal:  Dig Dis Sci       Date:  1997-12       Impact factor: 3.199

5.  Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat.

Authors:  N Mascolo; A A Izzo; F Barbato; F Capasso
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

6.  Loperamide inhibits gallbladder inflammatory fluid secretion in experimental cholecystitis.

Authors:  L Jivegård; J Svanvik
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-06       Impact factor: 3.000

7.  Local inhibition of myoelectrical activity of human colon by loperamide.

Authors:  I Altaparmakov; M Wienbeck
Journal:  Dig Dis Sci       Date:  1984-03       Impact factor: 3.199

8.  Characterization of the opiate receptor population mediating inhibition of VIP-induced secretion from the small intestine of the rat.

Authors:  I M Coupar
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

9.  Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action.

Authors:  A De Luca; I M Coupar
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-02       Impact factor: 3.000

10.  The action of loperamide in inhibiting prostaglandin-induced intestinal secretion in the rat.

Authors:  J Hardcastle; P T Hardcastle; N W Read; J S Redfern
Journal:  Br J Pharmacol       Date:  1981-11       Impact factor: 8.739
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