Literature DB >> 847235

The effect of loperamide on prostaglandin induced diarrhoea in rat and man.

S M Karim, P G Adaikan.   

Abstract

Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandins, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.

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Year:  1977        PMID： 847235     DOI： 10.1016/0090-6980(77)90011-9

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  32 in total

Review 1.  Pathogenesis and pharmacology of diarrhea.

Authors:  L Ooms; A Degryse
Journal:  Vet Res Commun       Date:  1986-09       Impact factor: 2.459

2.  Control of guinea pig intestinal electrolyte secretion by a delta-opiate receptor.

Authors:  J F Kachur; R J Miller; M Field
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

3.  Prostaglandin-induced diarrhoea.

Authors:  J A Dodge; I Hamdi; S Walker
Journal:  Arch Dis Child       Date:  1977-10       Impact factor: 3.791

4.  Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum.

Authors:  K J Moriarty; D D Rolston; M J Kelly; M Shield; M L Clark
Journal:  Gut       Date:  1985-01       Impact factor: 23.059

5.  Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide.

Authors:  E B Chang; D R Brown; N S Wang; M Field
Journal:  J Clin Invest       Date:  1986-07       Impact factor: 14.808

6.  The role of accelerated colonic transit in prostaglandin-induced diarrhoea and its inhibition by prostacyclin.

Authors:  B D Rush; M J Ruwart
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739

7.  Inhibition by loperamide of deoxycholic acid induced intestinal secretion.

Authors:  U M Farack; K Loeschke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-03       Impact factor: 3.000

8.  Disposition and metabolism of [14C]loperamide in rats.

Authors:  H Miyazaki; K Nambu; Y Matsunaga; M Hashimoto
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1979       Impact factor: 2.441

9.  Loperamide inhibits gallbladder inflammatory fluid secretion in experimental cholecystitis.

Authors:  L Jivegård; J Svanvik
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-06       Impact factor: 3.000

Review 10.  Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea.

Authors:  R C Heel; R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1978-01       Impact factor: 9.546
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