Literature DB >> 5263015

On the geometrical arrangement of the protein subunits of human serum low-density lipoprotein: evidence for a dodecahedral model.

H Pollard, A M Scanu, E W Taylor.   

Abstract

Ultracentrifugal and electron microscopic studies of human serum low-density lipoprotein (LDL) and several of its derivatives led to the formulation of a model in which the 20 protein subunits, probably globular, are arranged in a dodecahedral pattern with icosahedral symmetry. In such a model the LDL surface is occupied by both protein and lipids, predominantly phospholipids, as supported by the results of the hydrolysis of LDL by phospholipase A and C. Neutral lipids (cholesterol esters and glycerides) would be in the interior of the molecule.

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Year:  1969        PMID： 5263015      PMCID： PMC286162          DOI： 10.1073/pnas.64.1.304

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Solubilization and properties of the apoproteins of the very low- and low-density lipoproteins of human serum.

Authors:  J L Granda; A Scanu
Journal:  Biochemistry       Date:  1966-10       Impact factor: 3.162

2.  Properties of aqueous dispersions of phospholipid and cholesterol.

Authors:  K R Bruckdorfer; P A Edwards; C Green
Journal:  Eur J Biochem       Date:  1968-05

3.  Determination of the molecular weight of apoprotein subunits from low density lipoprotein by gel filtration.

Authors:  C E Day; R S Levy
Journal:  J Lipid Res       Date:  1968-11       Impact factor: 5.922

4.  An associating low-sulfur protein from wool.

Authors:  P D Jeffrey
Journal:  Biochemistry       Date:  1968-10       Impact factor: 3.162

Review 5.  Factors affecting lipoprotein metabolism.

Authors:  A M Scanu
Journal:  Adv Lipid Res       Date:  1965

6.  Partial delipidation of human serum beta-lipoprotein by sodium decyl sulfate.

Authors:  A M Gotto; R I Levy; F T Lindgren; D S Fredrickson
Journal:  Biochim Biophys Acta       Date:  1969-04-29

7.  On the conformational instability of human serum low-density lipoprotein: effect of temperature.

Authors:  A Scanu; H Pollard; R Hirz; K Kothary
Journal:  Proc Natl Acad Sci U S A       Date:  1969-01       Impact factor: 11.205

8.  The protein moiety of human serum beta-lipoproteins.

Authors:  B Shore; V Shore
Journal:  Biochem Biophys Res Commun       Date:  1967-09-27       Impact factor: 3.575

9.  Isopiestic compositions as a measure of preferential interactions of macromolecules in two-component solvents. Application to proteins in concentrated aqueous cesium chloride and guanidine hydrochloride.

Authors:  E P Hade; C Tanford
Journal:  J Am Chem Soc       Date:  1967-09-13       Impact factor: 15.419

10.  Properties of human serum low density lipoproteins after modification by succinic anhydride.

Authors:  A Scanu; H Pollard; W Reader
Journal:  J Lipid Res       Date:  1968-05       Impact factor: 5.922
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  16 in total

1.  Neutron scattering study of human serum low density lipoprotein.

Authors:  H B Stuhrmann; A Tardieu; L Mateu; C Sardet; V Luzzati; L Aggerbeck; A M Scanu
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

2.  Lipoprotein particles from the Golgi apparatus of guinea-pig liver.

Authors:  M J Chapman; G L Mills; C E Taylaur
Journal:  Biochem J       Date:  1972-07       Impact factor: 3.857

3.  The subunit structure of apoferritin and other eicosamers.

Authors:  R R Crichton
Journal:  Biochem J       Date:  1972-02       Impact factor: 3.857

4.  Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.

Authors:  J P Kane; D A Hardman; H E Paulus
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

5.  Subunit heterogeneity in human serum beta lipoprotein.

Authors:  J P Kane; E G Richards; R J Havel
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205

Review 6.  Low-density lipoproteins.

Authors:  B Lewis
Journal:  Biochem J       Date:  1971-07       Impact factor: 3.857

Review 7.  Optimized negative-staining electron microscopy for lipoprotein studies.

Authors:  Lei Zhang; Huimin Tong; Mark Garewal; Gang Ren
Journal:  Biochim Biophys Acta       Date:  2012-09-29

Review 8.  [Lipid-protein-interactions of human apolipoproteins-structural aspects and models of lipoproteins (author's transl)].

Authors:  G Middelhoff; J Augustin; G Klose; H Greten
Journal:  Klin Wochenschr       Date:  1977-02-15

9.  Cryoelectron microscopy of low density lipoprotein in vitreous ice.

Authors:  J M Spin; D Atkinson
Journal:  Biophys J       Date:  1995-05       Impact factor: 4.033

10.  A partial cDNA clone for human apolipoprotein B.

Authors:  S S Deeb; A G Motulsky; J J Albers
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205
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