Literature DB >> 5261043

Studies on the formation of transfer ribonucleic acid-ribosome complexes. XI. Antibiotic effects on phenylalanyl-oligonucleotide binding to ribosomes.

S Pestka.   

Abstract

The effect of antibiotics on the binding of phenylalanyl-oligonucleotide to ribosomes has been examined. The results show that many classes of antibiotics can interfere with binding of the aminoacyl-oligonucleotide terminus of tRNA to ribosomes: chloramphenicol, sparsomycin, D-WIN-5094, vernamycin A, PA114A, streptogramin, amicetin, gougerotin, tylosin, and spiramycin III. The results are consistent with the hypothesis that these antibiotics inhibit protein synthesis by interfering with the binding of the aminoacyl-end of aminoacyl-tRNA to ribosomes.

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Year:  1969        PMID： 5261043      PMCID： PMC223402          DOI： 10.1073/pnas.64.2.709

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  DIFFERENCES IN CHLORAMPHENICOL SENSITIVITY OF CELL-FREE AMINO ACID POLYMERIZATION SYSTEMS.

Authors:  Z KUCAN; F LIPMANN
Journal:  J Biol Chem       Date:  1964-02       Impact factor: 5.157

2.  Reaction of ribosome-bound peptidyl transfer ribonucleic acid with aminoacyl transfer ribonucleic acid or puromycin.

Authors:  M E Gottesman
Journal:  J Biol Chem       Date:  1967-12-10       Impact factor: 5.157

3.  The assimilation of amino-acids by bacteria. XV. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus.

Authors:  E F GALE; J P FOLKES
Journal:  Biochem J       Date:  1953-02       Impact factor: 3.857

4.  A ribosome-catalyzed reaction between N-formylmethionyl-trna and puromycin.

Authors:  A Zamir; P Leder; D Elson
Journal:  Proc Natl Acad Sci U S A       Date:  1966-12       Impact factor: 11.205

5.  Studies on the reaction of N-acetyl-phenylalanyl-tRNA with puromycin.

Authors:  H Weissbach; B Redfield; N Brot
Journal:  Arch Biochem Biophys       Date:  1968-09-20       Impact factor: 4.013

6.  Inhibition by sparsomycin and other antibiotics of the puromycin-induced release of polypeptide from ribosomes.

Authors:  I H Goldberg; K Mitsugi
Journal:  Biochemistry       Date:  1967-02       Impact factor: 3.162

7.  Studies on the formation of transfer ribonucleic acid-ribosome complexes. X. Phenylalanyl-oligonucleotide binding to ribosomes and the mechanism of chloramphenicol action.

Authors:  S Pestka
Journal:  Biochem Biophys Res Commun       Date:  1969-08-15       Impact factor: 3.575

8.  Action of sparsomycin on ribosome-catalysed peptidyl transfer.

Authors:  R E Monro; M L Celma; D Vazquez
Journal:  Nature       Date:  1969-04-26       Impact factor: 49.962

9.  Studies on the formation of trensfer ribonucleic acid-ribosome complexes. V. On the function of a soluble transfer factor in protein synthesis.

Authors:  S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

10.  Effect of limiting concentrations of T1 ribonuclease on the release of aminoacyl-oligonucleotides from unfractionated yeast acceptor RNA.

Authors:  E Herbert; C J Smith
Journal:  J Mol Biol       Date:  1967-09-14       Impact factor: 5.469
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  14 in total

1.  Inhibitors of protein synthesis V. Irreversible interaction of antibiotics with an initiation complex.

Authors:  C Coutsogeorgopoulos; J T Miller; D M Hann
Journal:  Nucleic Acids Res       Date:  1975-07       Impact factor: 16.971

Review 2.  Antibiotics of the virginiamycin family, inhibitors which contain synergistic components.

Authors:  C Cocito
Journal:  Microbiol Rev       Date:  1979-06

3.  Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation.

Authors:  Dmitri N Ermolenko; Peter V Cornish; Taekjip Ha; Harry F Noller
Journal:  RNA       Date:  2012-12-17       Impact factor: 4.942

4.  Proteins at the tRNA binding sites of Escherichia coli ribosomes.

Authors:  A P Czernilofsky; E E Collatz; G Stöffler; E Kuechler
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

5.  Complete nucleotide sequence of a 23S ribosomal RNA gene from Escherichia coli.

Authors:  J Brosius; T J Dull; H F Noller
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

6.  Polysome metabolism in Escherichia coli: amicetin, an antibiotic that stabilizes polysomes.

Authors:  H L Ennis
Journal:  Antimicrob Agents Chemother       Date:  1972-03       Impact factor: 5.191

7.  Studies on the formation of transfer ribonucleic acid-ribosomes complexes. XII. Phenylalanyl-oligonucleotide binding to E. coli ribosomes: necessity for a free amino group.

Authors:  T Hishizawa; J L Lessard; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205

8.  Identification of the chloramphenicol-binding protein in Escherichia coli ribosomes by partial reconstitution.

Authors:  D Nierhaus; K H Nierhaus
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

9.  Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomes.

Authors:  J Modolell; B Cabrer; A Parmeggiani; D Vazquez
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205

10.  Chloramphenicol-erythromycin resistance mutations in a 23S rRNA gene of Escherichia coli.

Authors:  M Ettayebi; S M Prasad; E A Morgan
Journal:  J Bacteriol       Date:  1985-05       Impact factor: 3.490
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