Literature DB >> 5261042

Esterolytic activity of elastase.

P Geneste, M L Bender.   

Abstract

The esters of L-alanine were found to be excellent substrates for elastase. The pH-dependence study using two methyl esters of this substrate showed the participation in the mechanism of an ionizing group with an apparent pK of 6.85 and a decrease of the activity at pH's greater than 10 (that could correspond to an apparent pK of 11.4).

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Year:  1969        PMID： 5261042      PMCID： PMC223398          DOI： 10.1073/pnas.64.2.683

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  6 in total

1.  RIBONUCLEASE E, AN INTERMEDIATE IN THE DEGRADATION OF RIBONUCLEASE BY PORCINE ELASTASE.

Authors:  W A KLEE
Journal:  J Biol Chem       Date:  1965-07       Impact factor: 5.157

2.  Purification and specificity of pancreatic elastase.

Authors:  M A NAUGHTON; F SANGER
Journal:  Biochem J       Date:  1961-01       Impact factor: 3.857

3.  The chemistry of connective tissues. 3. Composition of the soluble proteins derived from elastin.

Authors:  S M PARTRIDGE; H F DAVIS
Journal:  Biochem J       Date:  1955-09       Impact factor: 3.857

4.  The elastase-catalyzed hydrolysis of p-nitrophenyl trimethylacetate.

Authors:  M L Bender; T H Marshall
Journal:  J Am Chem Soc       Date:  1968-01-03       Impact factor: 15.419

5.  Evidence that the activity of elastase is not dependent on the ionization of its N-terminal amino group.

Authors:  H Kaplan; H Dugas
Journal:  Biochem Biophys Res Commun       Date:  1969-03-10       Impact factor: 3.575

6.  The determination of the concentration of hydrolytic enzyme solutions: alpha-chymotrypsin, trypsin, papain, elastase, subtilisin, and acetylcholinesterase.

Authors:  M L Bender; M L Begué-Cantón; R L Blakeley; L J Brubacher; J Feder; C R Gunter; F J Kézdy; J V Killheffer; T H Marshall; C G Miller; R W Roeske; J K Stoops
Journal:  J Am Chem Soc       Date:  1966-12-20       Impact factor: 15.419
  6 in total
  4 in total

1.  Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

Authors:  R A Ignotz; B Kelly; R J Davis; J Massagué
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

2.  Mechanism of inhibition of porcine elastase by human alpha-1-antitrypsin.

Authors:  H L James; A B Cohen
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808

3.  Evidence for an extended active center in elastase.

Authors:  R C Thompson; E R Blout
Journal:  Proc Natl Acad Sci U S A       Date:  1970-12       Impact factor: 11.205

4.  Catalytic properties of porcine pancreatic elastase: a steady-state and pre-steady-state study.

Authors:  P Ascenzi; E Menegatti; M Guarneri; E Antonini
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396
  4 in total

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