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Literature DB >> 3018723

Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

R A Ignotz, B Kelly, R J Davis, J Massagué.

Abstract

Retrovirus-transformed rat cells that actively express transforming growth factor type alpha (TGF-alpha) release into the medium a soluble protein of 17-19 kDa that has been identified as a precursor for TGF-alpha. The identification of this protein as a TGF-alpha precursor is based on its recognition by specific antibodies and by the ability of elastase to convert this protein into a 6-kDa polypeptide with the properties of mature TGF-alpha. This TGF-alpha precursor binds to epidermal growth factor/TGF-alpha receptors and activates the receptor-associated tyrosine kinase activity in intact cells. The biological potency of this precursor is not markedly increased by conversion into mature TGF-alpha in vitro. These studies demonstrate the ability of transformed cells to release a TGF-alpha precursor capable of strong mitogenic action in vivo.

Entities: Gene Species

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Year: 1986 PMID： 3018723 PMCID： PMC386492 DOI： 10.1073/pnas.83.17.6307

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

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Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

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Journal: Science Date: 1985-08-16 Impact factor: 47.728

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Journal: Proc Natl Acad Sci U S A Date: 1969-10 Impact factor: 11.205

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Journal: Nature Date: 1980-10-30 Impact factor: 49.962

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Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

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Authors: M B Sporn; G J Todaro
Journal: N Engl J Med Date: 1980-10-09 Impact factor: 91.245

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Authors: T Hunter; J A Cooper
Journal: Cell Date: 1981-06 Impact factor: 41.582

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Journal: Science Date: 1982-05-21 Impact factor: 47.728

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Journal: J Cell Physiol Date: 1981-10 Impact factor: 6.384

16 in total

1. N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity.

Authors: Pedro P Juanes; Laura Ferreira; Juan Carlos Montero; Joaquín Arribas; Atanasio Pandiella
Journal: Biochem J Date: 2005-07-01 Impact factor: 3.857

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Authors: S G Mueller; A J Paterson; J E Kudlow
Journal: Mol Cell Biol Date: 1990-09 Impact factor: 4.272

3. Broadening the Spectrum of Ehlers Danlos Syndrome in Patients With Congenital Adrenal Hyperplasia.

Authors: Rachel Morissette; Wuyan Chen; Ashley F Perritt; Jennifer L Dreiling; Andrew E Arai; Vandana Sachdev; Hwaida Hannoush; Ashwini Mallappa; Zhi Xu; Nazli B McDonnell; Martha Quezado; Deborah P Merke
Journal: J Clin Endocrinol Metab Date: 2015-06-15 Impact factor: 5.958

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Authors: A Pandiella; J Massagué
Journal: Proc Natl Acad Sci U S A Date: 1991-03-01 Impact factor: 11.205

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Authors: G P Briley; M A Hissong; M L Chiu; D C Lee
Journal: Mol Biol Cell Date: 1997-08 Impact factor: 4.138

6. Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.

Authors: J Gavrilović; G Moens; J P Thiery; J Jouanneau
Journal: Cell Regul Date: 1990-12

7. Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

Authors: P Anklesaria; J Teixidó; M Laiho; J H Pierce; J S Greenberger; J Massagué
Journal: Proc Natl Acad Sci U S A Date: 1990-05 Impact factor: 11.205