Animal experiments investigations on the action of topical corticoids on the normal guinea pig skin.

By means of the test procedure described, the action of topical corticosteroids on the untreated skin of guinea pigs may be exactly assessed and quantified. Of significance is the statistically verifiable observation that the steroid-induced epidermal hypoplasia is completely reversible after the withdrawal of the corticosteroid preparation. Moreover, the onset of a reactive epidermal spreading occurs, which exceeds the initial value to a small extent.