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Literature DB >> 5257005

Evidence for intergenic complementation in hybrid cells derived from two human diploid strains each carrying an X-linked mutation.

M Siniscalco, H P Klinger, H Eagle, H Koprowski, W Y Fujimoto, J E Seegmiller.

Abstract

Two male diploid fibroblast strains, each carrying deficiency mutations at different X-linked loci (glucose-6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyltransferase) have been successfully hybridized. The resulting mononucleated hybrid cells have been shown to synthesize both normal gene products, indicating that both X chromosomes are functionally active in the hybrid cells. We believe this is the first reported example of intergenic complementation in fused human diploid cells.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1969 PMID： 5257005 PMCID： PMC223668 DOI： 10.1073/pnas.62.3.793

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

11 in total

1. Amino acid metabolism in mammalian cell cultures.

Authors: H EAGLE
Journal: Science Date: 1959-08-21 Impact factor: 47.728

2. A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION.

Authors: M LESCH; W L NYHAN
Journal: Am J Med Date: 1964-04 Impact factor: 4.965

3. PROPERTIES ODF DIPLOID CELL STRAINS DEVELOPED FROM PATIENTS WITH AN INHERITED ABNORMALITY OF URIDINE BIOSYNTHESIS.

Authors: R S KROOTH
Journal: Cold Spring Harb Symp Quant Biol Date: 1964

4. A biochemical basis for resistance of L1210 mouse leukemia to 6-thioguanine.

Authors: P STUTTS; R W BROCKMAN
Journal: Biochem Pharmacol Date: 1963-02 Impact factor: 5.858

5. A single amino Acid substitution (asparagine to aspartic Acid) between normal (b+) and the common negro variant (a+) of human glucose-6-phosphate dehydrogenase.

Authors: A Yoshida
Journal: Proc Natl Acad Sci U S A Date: 1967-03 Impact factor: 11.205

6. Rescue of infectious SV40 after fusion between dfferent SV 40-transformed cells.

Authors: B B Knowles; F C Jensen; Z Steplewski; H Koprowski
Journal: Proc Natl Acad Sci U S A Date: 1968-09 Impact factor: 11.205

7. Activation of production of infectious tumor virus SV40 in heterokaryon cultures.

Authors: H Koprowski; F C Jensen; Z Steplewski
Journal: Proc Natl Acad Sci U S A Date: 1967-07 Impact factor: 11.205

8. A tetrazolium method for distinguishing between cultured human fibroblasts having eiter normal or deficient levels of glucose-6-phosphate dehydrogenase.

Authors: A Wajntal; R DeMars
Journal: Biochem Genet Date: 1967-06 Impact factor: 1.890

9. HYBRID CELLS DERIVED FROM MOUSE AND MAN: ARTIFICIAL HETEROKARYONS OF MAMMALIAN CELLS FROM DIFFERENT SPECIES.

Authors: H HARRIS; J F WATKINS
Journal: Nature Date: 1965-02-13 Impact factor: 49.962

10. Hurler's syndrome. A genetic study in cell culture.

Authors: B S Danes; A G Bearn
Journal: J Exp Med Date: 1966-01-01 Impact factor: 14.307

20 in total

1. Chromosomes of older humans are more prone to aminopterine-induced breakage.

Authors: D Esposito; G Fassina; P Szabo; P De Angelis; L Rodgers; M Weksler; M Siniscalco
Journal: Proc Natl Acad Sci U S A Date: 1989-02 Impact factor: 11.205

2. Mental retardation in heterozygotes for the fragile-X mutation: evidence in favor of an X inactivation-dependent effect.

Authors: M Rocchi; N Archidiacono; A Rinaldi; G Filippi; G Bartolucci; G S Fancello; M Siniscalco
Journal: Am J Hum Genet Date: 1990-04 Impact factor: 11.025

10. Isolation of mammalian cell mutants deficient in glucose 6-phosphate dehydrogenase by means of a replica-plating technique.

Authors: D Wild; B Hellkuhl
Journal: Hum Genet Date: 1976-06-29 Impact factor: 4.132

Evidence for intergenic complementation in hybrid cells derived from two human diploid strains each carrying an X-linked mutation.

1. Amino acid metabolism in mammalian cell cultures.

2. A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION.

3. PROPERTIES ODF DIPLOID CELL STRAINS DEVELOPED FROM PATIENTS WITH AN INHERITED ABNORMALITY OF URIDINE BIOSYNTHESIS.

4. A biochemical basis for resistance of L1210 mouse leukemia to 6-thioguanine.

5. A single amino Acid substitution (asparagine to aspartic Acid) between normal (b+) and the common negro variant (a+) of human glucose-6-phosphate dehydrogenase.

6. Rescue of infectious SV40 after fusion between dfferent SV 40-transformed cells.

7. Activation of production of infectious tumor virus SV40 in heterokaryon cultures.

8. A tetrazolium method for distinguishing between cultured human fibroblasts having eiter normal or deficient levels of glucose-6-phosphate dehydrogenase.

9. HYBRID CELLS DERIVED FROM MOUSE AND MAN: ARTIFICIAL HETEROKARYONS OF MAMMALIAN CELLS FROM DIFFERENT SPECIES.

10. Hurler's syndrome. A genetic study in cell culture.

1. Chromosomes of older humans are more prone to aminopterine-induced breakage.

2. Mental retardation in heterozygotes for the fragile-X mutation: evidence in favor of an X inactivation-dependent effect.

Review 3. Utilization of somatic cell hybrids for genetic studies in man.

4. Some aspects of somatic cell hybridization.

5. pH as a determinant of cellular growth and contact inhibition.

6. Esterase gene expression in Chinese hamster and mouse lymphoma hybrids isolated under nonselective pressure.

7. Altered enzymes in drug-resistant variants of mammalian tissue culture cells.

8. Isolation and analysis of somatic hybrids derived from two human diploid cells.

9. X-linkage of human phosphoglycerate kinase confirmed in man-mouse and man-Chinese hamster somatic cell hybrids.

10. Isolation of mammalian cell mutants deficient in glucose 6-phosphate dehydrogenase by means of a replica-plating technique.