Literature DB >> 5253663

Regulation of taste acuity by thiols and metal ions.

R I Henkin, D F Bradley.   

Abstract

The administration of thiol-containing drugs decreases taste acuity in man and animals. Copper (II) and zine (II) administration returns taste acuity to normal levels. The results suggest that (1) thiols and metals are in dynamic equilibrium in the metabolic net, (2) regulation of taste acuity occurs through changes which thiols and/or metals bring about in the conformation of a protein which lines the pore of the taste receptor and its membrane, and (3) thiols normally play an inhibitory role in taste.

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Year:  1969        PMID： 5253663      PMCID： PMC285950          DOI： 10.1073/pnas.62.1.30

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  SERUM SULFHYDRYL DETERMINATIONS AND SIGNIFICANCE IN CONNECTIVE TISSUE DISEASES.

Authors:  A LORBER; C M PEARSON; W L MEREDITH; L E GANTZ-MANDELL
Journal:  Ann Intern Med       Date:  1964-09       Impact factor: 25.391

2.  METAL CHELATES OF SOME SULFUR-CONTAINING AMINO ACIDS.

Authors:  G R LENZ; A E MARTELL
Journal:  Biochemistry       Date:  1964-06       Impact factor: 3.162

Review 3.  THE DISSOCIATION AND ASSOCIATION OF PROTEIN STRUCTURES.

Authors:  F J REITHEL
Journal:  Adv Protein Chem       Date:  1963

4.  STUDIES ON TASTE THRESHOLDS IN NORMAL MAN AND IN PATIENTS WITH ADRENAL CORTICAL INSUFFICIENCY: THE ROLE OF ADRENAL CORTICAL STEROIDS AND OF SERUM SODIUM CONCENTRATION.

Authors:  R I Henkin; J R Gill; F C Bartter
Journal:  J Clin Invest       Date:  1963-05       Impact factor: 14.808

5.  Decreased taste sensitivity after D-penicillamine reversed by copper administration.

Authors:  R I Henkin; H R Keiser; I A Jafee; I Sternlieb; I H Scheinberg
Journal:  Lancet       Date:  1967-12-16       Impact factor: 79.321

6.  Myositis ossificans traumatica with unusual course. Effect of EDTA on calcium, phosphorus and manganese excretion.

Authors:  U A Liberman; U Barzel; A De Vries; H Ellis
Journal:  Am J Med Sci       Date:  1967-07       Impact factor: 2.378

7.  Serum copper levels in rheumatoid arthritis: relationship of elevated copper to protein alterations.

Authors:  A Lorber; L S Cutler; C C Chang
Journal:  Arthritis Rheum       Date:  1968-02

8.  Excretion of trace elements in two penicillamine-treated cases of cystinuria.

Authors:  H Boström; P O Wester
Journal:  Acta Med Scand       Date:  1967-04

9.  Detection and study by fluorescence spectrometry of stereospecificity in mushroom tyrosinase-catalyzed oxidations. Proposal of a copper-containing reaction rate control site.

Authors:  W H Harrison; W W Whisler; S Ko
Journal:  J Biol Chem       Date:  1967-04-10       Impact factor: 5.157

10.  Auditory detection and perception in normal man and in patients with adrenal cortical insufficiency: effect of adrenal cortical steroids.

Authors:  R I Henkin; R L Daly
Journal:  J Clin Invest       Date:  1968-06       Impact factor: 14.808
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  9 in total

Review 1.  The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.

Authors:  Eric Block; Victor S Batista; Hiroaki Matsunami; Hanyi Zhuang; Lucky Ahmed
Journal:  Nat Prod Rep       Date:  2017-05-10       Impact factor: 13.423

2.  Gestational iron deficiency is associated with pica behaviors in adolescents.

Authors:  Rachel A Lumish; Sera L Young; Sunmin Lee; Elizabeth Cooper; Eva Pressman; Ronnie Guillet; Kimberly O O'Brien
Journal:  J Nutr       Date:  2014-08-13       Impact factor: 4.798

3.  A hypothesized unifying mechanism in neural function.

Authors:  D M Norris
Journal:  Experientia       Date:  1971-05-15

4.  Abnormalities of taste and smell after head trauma.

Authors:  P J Schechter; R I Henkin
Journal:  J Neurol Neurosurg Psychiatry       Date:  1974-07       Impact factor: 10.154

Review 5.  [Evaluating function and disorders of taste].

Authors:  H Rollin
Journal:  Arch Otorhinolaryngol       Date:  1975

6.  Crucial role of copper in detection of metal-coordinating odorants.

Authors:  Xufang Duan; Eric Block; Zhen Li; Timothy Connelly; Jian Zhang; Zhimin Huang; Xubo Su; Yi Pan; Lifang Wu; Qiuyi Chi; Siji Thomas; Shaozhong Zhang; Minghong Ma; Hiroaki Matsunami; Guo-Qiang Chen; Hanyi Zhuang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-10       Impact factor: 11.205

Review 7.  Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.

Authors:  R I Henkin
Journal:  Drug Saf       Date:  1994-11       Impact factor: 5.606

8.  Zinc in taste function : A critical review.

Authors:  R I Henkin
Journal:  Biol Trace Elem Res       Date:  1984-06       Impact factor: 3.738

Review 9.  Drug-induced neurological disorders.

Authors:  R J Lane; P A Routledge
Journal:  Drugs       Date:  1983-08       Impact factor: 9.546
  9 in total

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