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Literature DB >> 5167401

Theory of threshold fluctuations in nerves. II. Analysis of various sources of membrane noise.

Abstract

Threshold fluctuations in axon firing can arise as a result of electrical noise in the excitable membrane. A general theoretical expression for the fluctuations is applied to the analysis of three sources of membrane noise: Johnson noise, excess 1/f noise, and sodium conductance fluctuations. Analytical expressions for the width of the firing probability curve are derived for each of these noise sources. Specific calculations are performed for the node of Ranvier of the frog, and attention is given to the manner in which threshold fluctuations are affected by variations of temperature, ion concentrations, and the application of various drugs. Comparison with existing data suggests that threshold fluctuations can best be explained by sodium conductance fluctuations. Additional experiments directed at distinguishing among the various noise sources are proposed.

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Year: 1971 PMID： 5167401 PMCID： PMC1484102 DOI： 10.1016/S0006-3495(71)86278-1

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

9 in total

1. Sodium currents in the myelinated nerve fibre of Xenopus laevis investigated with the voltage clamp technique.

Authors: F A DODGE; B FRANKENHAEUSER
Journal: J Physiol Date: 1959-10 Impact factor: 5.182

2. Voltage-current relations in nerve cell membrane of Onchidium verruculatum.

Authors: S HAGIWARA; N SAITO
Journal: J Physiol Date: 1959-10 Impact factor: 5.182

3. The action of calcium on the electrical properties of squid axons.

Authors: B FRANKENHAEUSER; A L HODGKIN
Journal: J Physiol Date: 1957-07-11 Impact factor: 5.182

4. Theory of threshold fluctuations in nerves. I. Relationships between electrical noise and fluctuations in axon firing.

Authors: H Lecar; R Nossal
Journal: Biophys J Date: 1971-12 Impact factor: 4.033

5. Nerve membrane current noise: direct measurements under voltage clamp.

Authors: D J Poussart
Journal: Proc Natl Acad Sci U S A Date: 1969-09 Impact factor: 11.205

6. Fluctuations of resting neural membrane potential.

Authors: H E Derksen; A A Verveen
Journal: Science Date: 1966-03-18 Impact factor: 47.728

7. Membrane current noise in lobster axon under voltage clamp.

Authors: D J Poussart
Journal: Biophys J Date: 1971-02 Impact factor: 4.033

8. The nature of the negative resistance in bimolecular lipid membranes containing excitability-inducing material.

Authors: G Ehrenstein; H Lecar; R Nossal
Journal: J Gen Physiol Date: 1970-01 Impact factor: 4.086

9. TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS.

Authors: T NARAHASHI; J W MOORE; W R SCOTT
Journal: J Gen Physiol Date: 1964-05 Impact factor: 4.086

9 in total

25 in total

Theory of threshold fluctuations in nerves. II. Analysis of various sources of membrane noise.

1. Sodium currents in the myelinated nerve fibre of Xenopus laevis investigated with the voltage clamp technique.

2. Voltage-current relations in nerve cell membrane of Onchidium verruculatum.

3. The action of calcium on the electrical properties of squid axons.

4. Theory of threshold fluctuations in nerves. I. Relationships between electrical noise and fluctuations in axon firing.

5. Nerve membrane current noise: direct measurements under voltage clamp.

6. Fluctuations of resting neural membrane potential.

7. Membrane current noise in lobster axon under voltage clamp.

8. The nature of the negative resistance in bimolecular lipid membranes containing excitability-inducing material.

9. TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS.

1. Subthreshold voltage noise due to channel fluctuations in active neuronal membranes.

2. Potassium and sodium ion current noise in the membrane of the squid giant axon.

3. State-dependent effects of Na channel noise on neuronal burst generation.

4. Detailed numerical investigation of the dissipative stochastic mechanics based neuron model.

5. Dynamical instability determines the effect of ongoing noise on neural firing.

Review 6. The benefits of noise in neural systems: bridging theory and experiment.

7. Spontaneous action potentials due to channel fluctuations.

8. Stochastic versions of the Hodgkin-Huxley equations.

9. Noise-induced neural impulses.

10. A threshold equation for action potential initiation.