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Literature DB >> 5157136

Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes.

Abstract

Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.

Entities: Chemical Species

Mesh：

Substances：
Glycogen
Rifampin

Year: 1971 PMID： 5157136 PMCID： PMC1412001 DOI： 10.1136/gut.12.12.984

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

12 in total

Review 1. Organelle pathology of the liver. The endoplasmic reticulum.

Authors: R J Stenger
Journal: Gastroenterology Date: 1970-04 Impact factor: 22.682

2. The normal human liver cell. Cytochemical and ultrastructural studies.

Authors: M H Ma; L Biempica
Journal: Am J Pathol Date: 1971-03 Impact factor: 4.307

3. [Pharmacokinetics of rifomycin].

Authors: G Curci; A Ninni; F Iodice
Journal: Acta Tuberc Pneumol Belg Date: 1969

4. Reduction in serum bilirubin by phenobarbital in adult unconjugated hyperhilirubinaemia. Is enzyme induction responsible?

Authors: M J Whelton; L P Krustev; B H Billing
Journal: Am J Med Date: 1968-07 Impact factor: 4.965

5. The effect of an intravenous infusion of rifamycin SV on the excretion of bilirubin, bromsulphalein, and indocyanine green in man.

Authors: G Acocella; F B Nicolis; L T Tenconi
Journal: Gastroenterology Date: 1965-11 Impact factor: 22.682

6. The effect of rifamycin SV on pigment excretion in rats.

Authors: G Acocella; B H Billing
Journal: Gastroenterology Date: 1965-11 Impact factor: 22.682

Review 7. Chemical and biological properties of rifampicin.

Authors: S Furesz
Journal: Antibiot Chemother Date: 1970

8. Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes.

Authors: E Rubin; F Hutterer; C S Lieber
Journal: Science Date: 1968-03-29 Impact factor: 47.728

9. Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus.

Authors: J F Crigler; N I Gold
Journal: J Clin Invest Date: 1969-01 Impact factor: 14.808

10. Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol.

Authors: E Rubin; C S Lieber
Journal: Science Date: 1968-11-08 Impact factor: 47.728

23 in total

1. Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance.

Authors: W Zilly; D D Breimer; E Richter
Journal: Eur J Clin Pharmacol Date: 1975-12-19 Impact factor: 2.953

6. Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.

Authors: W Zilly; D D Breimer; E Richter
Journal: Eur J Clin Pharmacol Date: 1977-04-20 Impact factor: 2.953

7. Alterations of glucocorticoid actions by other drugs and disease states.

Authors: W Jubiz; A W Meikle
Journal: Drugs Date: 1979-08 Impact factor: 9.546

8. Serum concentration and half-life of rifampicin after simultaneous oral administration of aminosalicylic acid or isoniazid.

Authors: G Boman
Journal: Eur J Clin Pharmacol Date: 1974 Impact factor: 2.953

9. [Postmortem evaluation of barbiturate poisonings].

Authors: A Schmoldt; E R Beckmann; W Horstmann
Journal: Z Rechtsmed Date: 1984

Review 10. Clinical pharmacokinetics of rifampicin.

Authors: G Acocella
Journal: Clin Pharmacokinet Date: 1978 Mar-Apr Impact factor: 6.447