Literature DB >> 5687818

Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol.

E Rubin, C S Lieber.   

Abstract

The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.

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Year:  1968        PMID： 5687818     DOI： 10.1126/science.162.3854.690

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  50 in total

1.  The effect of ethanol on drug oxidations in vitro and the significance of ethanol-cytochrome P-450 interaction.

Authors:  D L Cinti; R Grundin; S Orrenius
Journal:  Biochem J       Date:  1973-06       Impact factor: 3.857

2.  A human PBPK model for ethanol describing inhibition of gastric motility.

Authors:  George D Loizou; Martin Spendiff
Journal:  J Mol Histol       Date:  2004-09       Impact factor: 2.611

3.  Effect of a single oral dose of methanol, ethanol and propan-2-ol on the hepatic microsomal metabolism of foreign compounds in the rat.

Authors:  G Powis
Journal:  Biochem J       Date:  1975-05       Impact factor: 3.857

4.  [Deaths resulting from combined action of alcohol and drug intake (author's transl)].

Authors:  M Geldmacher v Mallinckrodt; A Zober; J Dumbach; J H Geldmacher; L Lautenbach; G Machbert; G Reinhardt; G Schaidt; B Schellmann; W Schütz; H B Wuermeling; P Zink
Journal:  Z Rechtsmed       Date:  1976-08-26

5.  Histological changes in the liver and indices of drug metabolism in alcoholics.

Authors:  E A Sotaniemi; J Ahlqvist; R O Pelkonen; H Pirttiaho; P V Luoma
Journal:  Eur J Clin Pharmacol       Date:  1977-04-20       Impact factor: 2.953

6.  Alcohol and bupropion pharmacokinetics in healthy male volunteers.

Authors:  J Posner; A Bye; S Jeal; A W Peck; P Whiteman
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

7.  Effect of ethanol on the urinary excretion of mandelic and phenylglyoxylic acids after human exposure to styrene.

Authors:  S Cerný; J Mráz; J Flek; M Tichý
Journal:  Int Arch Occup Environ Health       Date:  1990       Impact factor: 3.015

8.  Effect of ethanol on microsomal metabolism of dimethylnitrosamine.

Authors:  M Schwarz; K E Appel; D Schrenk; W Kunz
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

9.  Pathogenesis of postprandial hyperlipemia in rats fed ethanol-containing diets.

Authors:  E Baraona; R C Pirola; C S Lieber
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808

10.  Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.

Authors:  A Sato; T Nakajima; Y Koyama
Journal:  Br J Ind Med       Date:  1980-11
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