Literature DB >> 5144269

Properties of lubrol-extracted uridine diphosphate glucuronyltransferase.

R D Howland, A Burkhalter, A J Trevor, S Hegeman, D Y Shirachi.   

Abstract

1. A partially purified UDP-glucuronyltransferase was obtained by extracting rat liver microsomal preparations with Lubrol, a non-ionic detergent. 2. The soluble enzyme catalysed conjugation of both o-aminophenol and p-nitrophenol and was extremely stable when compared with untreated microsomal preparations. 3. The characteristics of the conjugation of the two phenols were found to differ with respect to pH optimum, bivalent cation requirement and Michaelis constants, suggesting that more than one enzyme is involved in the conjugation reaction.

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Year:  1971        PMID： 5144269      PMCID： PMC1178261          DOI： 10.1042/bj1250991

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of ester, aliphatic and steroid glucuronides.

Authors:  G J DUTTON
Journal:  Biochem J       Date:  1956-12       Impact factor: 3.857

2.  Uridine compounds in glucuronic acid metabolism. I. The formation of glucuronides in liver suspensions.

Authors:  G J DUTTON; I D STOREY
Journal:  Biochem J       Date:  1954-06       Impact factor: 3.857

3.  Spontaneous and detergent activation of a glucuronyltransferase in vitro.

Authors:  K K Lueders; E L Kuff
Journal:  Arch Biochem Biophys       Date:  1967-04       Impact factor: 4.013

4.  Studies on bilirubin UDP-glucuronyltransferase.

Authors:  E Halac; A Reff
Journal:  Biochim Biophys Acta       Date:  1967-07-11

5.  Studies of glucuronidation. IV. Evidences of different processes for o-aminophenol and p-nitrophenol.

Authors:  A R Temple; M S Clement; A K Done
Journal:  Proc Soc Exp Biol Med       Date:  1968-05

6.  Partial purification of hepatic UDP-glucuronyltransferase. Studies of some of its properties.

Authors:  A P Mowat; I M Arias
Journal:  Biochim Biophys Acta       Date:  1970-07-15

7.  The effect of phenobarbital on the submicrosomal distribution of uridine diphosphate glucuronyltransferase from rat liver.

Authors:  G J Mulder
Journal:  Biochem J       Date:  1970-04       Impact factor: 3.857

8.  Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor.

Authors:  F P Van Roy; K P Heirwegh
Journal:  Biochem J       Date:  1968-04       Impact factor: 3.857

9.  The submicrosomal distribution of hepatic uridine diphosphate glucuronyltransferases in the rabbit.

Authors:  T E Gram; A R Hansen; J R Fouts
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

10.  SOME DIFFERENCES IN THE CONJUGATION OF O-AMINOPHENOL AND P-NITROPHENOL BY THE URIDINE DIPHOSPHATE TRANSGLUCURONYLASE OF MOUSE-LIVER HOMOGENATES.

Authors:  I D STOREY
Journal:  Biochem J       Date:  1965-04       Impact factor: 3.857
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  6 in total

1.  Comparison of uridine diphosphate glucuronyltransferase activities synthesizing S- and O-beta-D-glucuronides.

Authors:  H P Illing; G J Dutton
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857

2.  Studies on the purification of rat liver uridine diphosphate glucuronyltransferase.

Authors:  B Burchell
Journal:  Biochem J       Date:  1977-03-01       Impact factor: 3.857

3.  Product inhibition of o-aminophenol glucuronidation by p-nitrophenyl glucuronide in detergent-treated microsomal fractions.

Authors:  R D Howland
Journal:  Biochem J       Date:  1978-09-15       Impact factor: 3.857

4.  A rapid NAD+-linked assay for microsomal uridine diphosphate glucuronyltransferase of rat liver and some observations on substrate specificity of the enzyme.

Authors:  G J Mulder; A B van Doorn
Journal:  Biochem J       Date:  1975-10       Impact factor: 3.857

5.  Possible multiple binding sites for o-aminophenol on uridine diphosphate glucuronyltransferase.

Authors:  R D Howland; L D Bohm
Journal:  Biochem J       Date:  1977-04-01       Impact factor: 3.857

6.  Some properties of the uridine diphosphate glucuronyltransferase activity synthesizing thio-beta-D-glucuronides.

Authors:  H P Illing; G J Dutton
Journal:  Biochem J       Date:  1973-01       Impact factor: 3.857
  6 in total

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