Literature DB >> 5133099

Mechanism of the -chymotrypsin-catalyzed hydrolysis of amides. pH dependence of k c and K m . Kinetic detection of an intermediate.

A R Fersht, Y Requena.   

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Year:  1971        PMID: 5133099     DOI: 10.1021/ja00754a066

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


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  7 in total

1.  Influence of Leaving-Group Electronic Effect on alpha-Chymotrypsin: Catalytic Constants of Specific Substrates.

Authors:  M Philipp; R M Pollack; M L Bender
Journal:  Proc Natl Acad Sci U S A       Date:  1973-02       Impact factor: 11.205

2.  Protonation linked equilibria and apparent affinity constants: the thermodynamic profile of the alpha-chymotrypsin-proflavin interaction.

Authors:  Gilles Bruylants; René Wintjens; Yvan Looze; Christina Redfield; Kristin Bartik
Journal:  Eur Biophys J       Date:  2007-04-19       Impact factor: 1.733

3.  pH dependency of the carboxyl oxygen exchange reaction catalyzed by lysyl endopeptidase and trypsin.

Authors:  Dagmar Hajkova; K C Sekhar Rao; Masaru Miyagi
Journal:  J Proteome Res       Date:  2006-07       Impact factor: 4.466

4.  Do cleavages of amides by serine proteases occur through a stepwise pathway involving tetrahedral intermediates?

Authors:  M Komiyama; M L Bender
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

5.  Acylation of alpha-chymotrypsin by oxygen and sulfur esters of specific substrates: kinetic evidence for a tetrahedral intermediate.

Authors:  H Hiroara; M L Bender; R S Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

6.  13C high-resolution nuclear magnetic resonance studies of enzyme-substrate reactions at equilibrium. Substrate studies of chymotrypsin-N-acetyltyrosine semicarbazide complexes.

Authors:  G Robillard; E Shaw; R G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

7.  Kinetic Studies of the Effect of pH on the Trypsin-Catalyzed Hydrolysis of N-α-benzyloxycarbonyl-l-lysine-p-nitroanilide: Mechanism of Trypsin Catalysis.

Authors:  J Paul G Malthouse
Journal:  ACS Omega       Date:  2020-03-03
  7 in total

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