Literature DB >> 5123421

Creation of "amyloid" fibrils from Bence Jones proteins in vitro.

G G Glenner, D Ein, E D Eanes, H A Bladen, W Terry, D L Page.   

Abstract

"Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, beta-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested.

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Year:  1971        PMID： 5123421     DOI： 10.1126/science.174.4010.712

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  72 in total

1.  Physicochemical consequences of amino acid variations that contribute to fibril formation by immunoglobulin light chains.

Authors:  R Raffen; L J Dieckman; M Szpunar; C Wunschl; P R Pokkuluri; P Dave; P Wilkins Stevens; X Cai; M Schiffer; F J Stevens
Journal:  Protein Sci       Date:  1999-03       Impact factor: 6.725

2.  Monitoring the assembly of Ig light-chain amyloid fibrils by atomic force microscopy.

Authors:  C Ionescu-Zanetti; R Khurana; J R Gillespie; J S Petrick; L C Trabachino; L J Minert; S A Carter; A L Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

3.  Two prion-inducing regions of Ure2p are nonoverlapping.

Authors:  M L Maddelein; R B Wickner
Journal:  Mol Cell Biol       Date:  1999-06       Impact factor: 4.272

4.  Cellular mechanism of fibril formation from serum amyloid A1 protein.

Authors:  Stephanie Claus; Katrin Meinhardt; Tobias Aumüller; Ioana Puscalau-Girtu; Julia Linder; Christian Haupt; Paul Walther; Tatiana Syrovets; Thomas Simmet; Marcus Fändrich
Journal:  EMBO Rep       Date:  2017-06-21       Impact factor: 8.807

Review 5.  Nanotools for megaproblems: probing protein misfolding diseases using nanomedicine modus operandi.

Authors:  Vladimir N Uversky; Alexander V Kabanov; Yuri L Lyubchenko
Journal:  J Proteome Res       Date:  2006-10       Impact factor: 4.466

6.  Intralysosomal formation of amyloid fibrils.

Authors:  T Shirahama; A S Cohen
Journal:  Am J Pathol       Date:  1975-10       Impact factor: 4.307

7.  Editorial: Newer concepts in amyloidogenesis.

Authors:  A Katz; W Pruzanski
Journal:  Can Med Assoc J       Date:  1976-05-22       Impact factor: 8.262

8.  Nature of amyloid deposits in hypernephroma. Immunocytochemical studies in 2 cases associated with amyloid polyneuropathy.

Authors:  M C Dalakas; S Fujihara; V Askanas; W K Engel; G G Glenner
Journal:  Am J Pathol       Date:  1984-09       Impact factor: 4.307

9.  Experimental paracoccidioidomycosis in the Syrian hamster: morphology, ultrastructure and correlation of lesions with presence of specific antigens and serum levels of antibodies.

Authors:  K Iabuki; M R Montenegro
Journal:  Mycopathologia       Date:  1979-07-16       Impact factor: 2.574

10.  Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.

Authors:  Bonnie K Arendt; Marina Ramirez-Alvarado; Laura A Sikkink; Jonathan J Keats; Gregory J Ahmann; Angela Dispenzieri; Rafael Fonseca; Rhett P Ketterling; Ryan A Knudson; Erin M Mulvihill; Renee C Tschumper; Xiaosheng Wu; Steven R Zeldenrust; Diane F Jelinek
Journal:  Blood       Date:  2008-06-20       Impact factor: 22.113
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