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Literature DB >> 5119782

Formation of malate from glyoxylate in animal tissues.

Abstract

1. Incubation of rat liver homogenate with [1-(14)C]glyoxylate, ATP and acetate shows a rapid sequential incorporation of radioactivity into malate, oxaloacetate and citrate. 2. In liver from normal rats the rate of the formation of each substance in question is higher than that in liver from thiamin-deficient rats. 3. The net accumulation of malate is greater with liver from thiamin-deficient rats. Its further metabolism is retarded, it is suggested, by inhibitors formed by a condensation of glyoxylate and oxaloacetate.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5119782 PMCID： PMC1176592 DOI： 10.1042/bj1210447

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

1. THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.

Authors: K KURATOMI; K FUKUNAGA
Journal: Biochim Biophys Acta Date: 1963-12-13

2. The inhibition of several tricarboxylic acid cycle enzymes by gamma-hydroxy- alpha-ketoglutarate.

Authors: B PAYES; G G LATIES
Journal: Biochem Biophys Res Commun Date: 1963-03-25 Impact factor: 3.575

3. Control of the citric acid cycle by glyoxylate. 2. Mechanism of the inhibition of respiration in liver and kidney particles.

Authors: A RUFFO; A ADINOLFI; G BUDILLON; G CAPOBIANCO
Journal: Biochem J Date: 1962-12 Impact factor: 3.857

Formation of malate from glyoxylate in animal tissues.

1. THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.

2. The inhibition of several tricarboxylic acid cycle enzymes by gamma-hydroxy- alpha-ketoglutarate.

3. Control of the citric acid cycle by glyoxylate. 2. Mechanism of the inhibition of respiration in liver and kidney particles.

4. Studies on experimental thiamine deficiency. 3. Glyoxylic acid, citric acid and tissue metabolism.

5. Catabolism of glycine in Rhodopseudomonas spheroides.

6. Isocitritase; enzyme properties and reaction equilibrium.

7. Distribution and Properties of Isocitritase in Plants.

8. The scope of the transamination reaction in animal tissues.

Review 9. [Reactivity of glyoxylates and regulation of the citric acid cycle in animal tissues].

10. The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria.

1. Metabolic changes in rats during developing thiamin deficiency.

2. Introduction and expression of the bacterial glyoxylate cycle genes in transgenic mice.

3. Cytochemical localization of malate synthase in glyoxysomes.