Literature DB >> 5119625

Amino acid composition of proteins as a product of molecular evolution.

T Ohta, M Kimura.   

Abstract

The average amino acid composition of proteins is determined by the genetic code and by random base changes in evolution. Small but significant deviations from expected composition can be explained by selective constraint on amino acid substitutions. In particular, the deficiency of arginine in proteins has been caused by constraint, during evolution, on fixation of mutations substituting arginine for other amino acids.

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Year:  1971        PMID： 5119625     DOI： 10.1126/science.174.4005.150

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Entropy of the genetic information and evolution.

Authors:  M Hasegawa; T A Yano
Journal:  Orig Life       Date:  1975 Jan-Apr

2.  Comments on counter-examples to a neutralist hypothesis by Lila L. Gatlin.

Authors:  T H Jukes
Journal:  J Mol Evol       Date:  1976-10-27       Impact factor: 2.395

3.  Further comments on "Counter-examples to a neutralist hypothesis".

Authors:  M Kimura; T Ohta
Journal:  J Mol Evol       Date:  1977-08-05       Impact factor: 2.395

4.  Evolutionary changes in protein composition -- evidence for an optimal strategy.

Authors:  R Coutelle; G L Hofacker; R D Levine
Journal:  J Mol Evol       Date:  1979-06-08       Impact factor: 2.395

5.  Entropy increase of amino acid sequence in protein.

Authors:  T Yano; M Hasegawa
Journal:  J Mol Evol       Date:  1974-11-29       Impact factor: 2.395

6.  Conservation of Shannon's redundancy for proteins.

Authors:  L L Gatlin
Journal:  J Mol Evol       Date:  1974       Impact factor: 2.395

7.  On the cysteine and cystine content of proteins. Differences between intracellular and extracellular proteins.

Authors:  R C Fahey; J S Hunt; G C Windham
Journal:  J Mol Evol       Date:  1977-11-25       Impact factor: 2.395

8.  Genome wide exploration of the origin and evolution of amino acids.

Authors:  Xiaoxia Liu; Jingxian Zhang; Feng Ni; Xu Dong; Bucong Han; Daxiong Han; Zhiliang Ji; Yufen Zhao
Journal:  BMC Evol Biol       Date:  2010-03-15       Impact factor: 3.260

9.  Heterogeneity of storage proteins in maize.

Authors:  P G Righetti; E Gianazza; A Viotti; C Soave
Journal:  Planta       Date:  1977-01       Impact factor: 4.116

10.  Inferring selection on amino acid preference in protein domains.

Authors:  Alan M Moses; Richard Durbin
Journal:  Mol Biol Evol       Date:  2008-12-18       Impact factor: 16.240
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