Literature DB >> 5115829

A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474.

M P Cole, C T Jones, I D Todd.   

Abstract

An introductory clinical trial of the anti-oestrogenic agent IC146474 in late or recurrent carcinoma of the breast is described.Forty-six patients have been treated, of whom 10 have shown a good response. This is of the same order as that seen with oestrogens and androgens.The particular advantage of this drug is the low incidence of troublesome side effects.

Entities:  

Mesh:

Substances:

Year:  1971        PMID: 5115829      PMCID: PMC2008453          DOI: 10.1038/bjc.1971.33

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  2 in total

1.  Role of estrogens in ovulation: A study using the estrogen-antagonist, I.C.I. 46,474.

Authors:  A P Labhsetwar
Journal:  Endocrinology       Date:  1970-09       Impact factor: 4.736

2.  New synthetic agent for the induction of ovulation: preliminary trials in women.

Authors:  A Klopper; M Hall
Journal:  Br Med J       Date:  1971-01-16
  2 in total
  157 in total

1.  Suppression of Estrogenic Activity by Medroxyprogesterone Acetate in Tamoxifen-treated Patients after Surgery for Breast Cancer to Reduce the Risk of Endometrial Cancer Development.

Authors: 
Journal:  Breast Cancer       Date:  1996-03-29       Impact factor: 4.239

Review 2.  The changing role of ER in endocrine resistance.

Authors:  Agostina Nardone; Carmine De Angelis; Meghana V Trivedi; C Kent Osborne; Rachel Schiff
Journal:  Breast       Date:  2015-08-10       Impact factor: 4.380

Review 3.  The estrogen receptor: a logical target for the prevention of breast cancer with antiestrogens.

Authors:  D A Tonetti; V C Jordan
Journal:  J Mammary Gland Biol Neoplasia       Date:  1999-10       Impact factor: 2.673

4.  Gynaecomastia associated with gonadotrophin-secreting carcinoma of the lung.

Authors:  D Fairlamb; E Boesen
Journal:  Postgrad Med J       Date:  1977-05       Impact factor: 2.401

5.  Tamoxifen in the management of metastatic cancer of the breast.

Authors:  L A Cone; N E Romanoff; N A Helm
Journal:  West J Med       Date:  1979-09

Review 6.  New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.

Authors:  V Craig Jordan
Journal:  Steroids       Date:  2007-07-27       Impact factor: 2.668

7.  In search of novel drug target sites on estrogen receptors using RNA aptamers.

Authors:  Daiying Xu; Vamsee-Krishna Chatakonda; Antonis Kourtidis; Douglas S Conklin; Hua Shi
Journal:  Nucleic Acid Ther       Date:  2014-03-03       Impact factor: 5.486

Review 8.  The role of aromasin in the hormonal therapy of breast cancer.

Authors:  Magdolna Dank
Journal:  Pathol Oncol Res       Date:  2002       Impact factor: 3.201

9.  Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.

Authors:  Robert Clarke; Ayesha N Shajahan; Rebecca B Riggins; Younsook Cho; Anatasha Crawford; Jianhua Xuan; Yue Wang; Alan Zwart; Ruchi Nehra; Minetta C Liu
Journal:  J Steroid Biochem Mol Biol       Date:  2009-03       Impact factor: 4.292

10.  Effect of the anti-oestrogen tamoxifen on the development of renal cortical necrosis induced by oestrone + vasopressin administration in rats.

Authors:  J Kocsis; G Karácsony; S Karcsú; F A László
Journal:  Br J Exp Pathol       Date:  1988-04
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.