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Literature DB >> 511297

Arachidonic acid aggregates neutrophils.

J T O'Flaherty, H S Showell, E L Becker, P A Ward.

Abstract

Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 511297 DOI： 10.1007/bf00913500

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

14 in total

1. A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.

Authors: G A Higgs; E McCall; L J Youlten
Journal: Br J Pharmacol Date: 1975-04 Impact factor: 8.739

2. Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.

Authors: J B Smith; C Ingerman; M J Silver
Journal: J Clin Invest Date: 1976-11 Impact factor: 14.808

Review 3. Prostaglandins and thromboxanes: biochemical and physiological considerations.

Authors: B Samuelsson; G Folco; E Granström; H Kindahl; C Malmsten
Journal: Adv Prostaglandin Thromboxane Res Date: 1978

4. Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2.

Authors: B B Vargaftig; P Zirinis
Journal: Nat New Biol Date: 1973-07-25

5. Chemotactic factor influences on the aggregation, swelling, and foreign surface adhesiveness of human leukocytes.

Authors: J T O'Flaherty; D L Kreutzer; P A Ward
Journal: Am J Pathol Date: 1978-03 Impact factor: 4.307

6. Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.

Authors: P Borgeat; M Hamberg; B Samuelsson
Journal: J Biol Chem Date: 1976-12-25 Impact factor: 5.157

7. Substances which aggregate neutrophils. Mechanism of action.

Authors: J T O'Flaherty; H J Showell; E L Becker; P A Ward
Journal: Am J Pathol Date: 1978-07 Impact factor: 4.307

8. Acetylenic analog of arachidonate that acts like aspirin on platelets.

Authors: A L Willis; D C Kuhn; H J Weiss
Journal: Science Date: 1974-01-25 Impact factor: 47.728

9. Remodeling of granulocyte membrane fatty acids during phagocytosis.

Authors: J E Smolen; S B Shohet
Journal: J Clin Invest Date: 1974-03 Impact factor: 14.808

10. Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes.

Authors: E A Kitchen; J R Boot; W Dawson
Journal: Prostaglandins Date: 1978-08

8 in total

1. Arachidonic acid and LTB4 enhance aggregation of psoriatic peripheral blood mononuclear leukocytes in vitro.

Authors: P D Pigatto; M M Polenghi; G F Altomare; G L Tadini; S Villa
Journal: Arch Dermatol Res Date: 1987 Impact factor: 3.017

Review 2. Cellular and humoral mediators of pulmonary edema.

Authors: A B Malik; W M Selig; K E Burhop
Journal: Lung Date: 1985 Impact factor: 2.584

3. Effect of calcium, magnesium, and cytochalasin B on arachidonic acid-induced neutrophil aggregation.

Authors: J T O'Flaherty
Journal: Inflammation Date: 1980-03 Impact factor: 4.092

4. Gram-positive bacteria-induced granulocytopenia and pulmonary leukostasis in rabbits.

Authors: S E Goldblum; W P Reed
Journal: Infect Immun Date: 1982-07 Impact factor: 3.441

5. Aggregation of polymorphonuclear leucocytes (PMNs) by leukotriene B4: effects of cyclooxygenase products and metabolic inhibitors.

Authors: F M Cunningham; H R Carter; M J Smith; A W Ford-Hutchinson; M A Bray
Journal: Agents Actions Date: 1981-12