Literature DB >> 5111997

Disposition of morphine in man.

S Spector, E S Vesell.   

Abstract

The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose (10 milligrams per 70 kilograms) was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study. A multiphasic decline in serum concentrations of morphine occurred. Detectable blood concentrations of morphine, or of a metabolite, or of both persisted for 48 hours after a single intravenous dose.

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Year:  1971        PMID： 5111997     DOI： 10.1126/science.174.4007.421

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Pharmacokinetics of morphine in plasma and discrete areas of the rat brain.

Authors:  B E Dahlström; L K Paalzow
Journal:  J Pharmacokinet Biopharm       Date:  1975-10

Review 2.  Naloxone dosage for opioid reversal: current evidence and clinical implications.

Authors:  Rachael Rzasa Lynn; J L Galinkin
Journal:  Ther Adv Drug Saf       Date:  2017-12-13

3.  Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations.

Authors:  J Hasselström; J Säwe
Journal:  Clin Pharmacokinet       Date:  1993-04       Impact factor: 6.447

4.  Patient-controlled analgesic therapy, Part IV: pharmacokinetics and analgesic plasma concentrations of morphine.

Authors:  B Dahlström; A Tamsen; L Paalzow; P Hartvig
Journal:  Clin Pharmacokinet       Date:  1982 May-Jun       Impact factor: 6.447

Review 5.  High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment.

Authors:  J Säwe
Journal:  Clin Pharmacokinet       Date:  1986 Mar-Apr       Impact factor: 6.447

Review 6.  Pharmacokinetics of drug overdose.

Authors:  J Rosenberg; N L Benowitz; S Pond
Journal:  Clin Pharmacokinet       Date:  1981 May-Jun       Impact factor: 6.447

Review 7.  Pharmacology of morphine in obese patients: clinical implications.

Authors:  Célia Lloret Linares; Xavier Declèves; Jean Michel Oppert; Arnaud Basdevant; Karine Clement; Christophe Bardin; Jean Michel Scherrmann; Jean Pierre Lepine; Jean François Bergmann; Stéphane Mouly
Journal:  Clin Pharmacokinet       Date:  2009       Impact factor: 6.447

8.  PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury.

Authors:  Neil C Lax; Renxun Chen; Sarah R Leep; Kathryn Uhrich; Lei Yu; Benedict Kolber
Journal:  Mol Pain       Date:  2017 Jan-Dec       Impact factor: 3.395
  8 in total

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