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Literature DB >> 5105387

Disturbed patterns of behaviour in morphine tolerant and abstinent rats.

Abstract

1. Eating, drinking and spontaneous motor activity were studied in rats receiving large daily doses of morphine. These forms of behaviour were largely suppressed when the rats were made abstinent and were restored when morphine was given again.2. Compensation for depressions of behaviour during abstinence did not seem sufficient to account for all the stimulant effects of morphine in tolerant rats. Morphine also had slight stimulant actions in non-tolerant rats.3. In tolerant rats, the repeated pairing of the effects of morphine with the re-emergence of behaviour such as eating and drinking may intensify the rewarding value of the drug.

Entities: Chemical Disease Species

Mesh：

Substances：
Morphine

Year: 1971 PMID： 5105387 PMCID： PMC1665671 DOI： 10.1111/j.1476-5381.1971.tb07132.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

27 in total

1. TOLERANCE TO AND PHYSICAL DEPENDENCE ON MORPHINE IN RATS.

Authors: W R MARTIN; A WIKLER; C G EADES; F T PESCOR
Journal: Psychopharmacologia Date: 1963-05-21

2. RELATIONSHIP BETWEEN WATER AND FOOD INGESTION IN THE RAT.

Authors: L J CIZEK; M R NOCENTI
Journal: Am J Physiol Date: 1965-04

3. Comparison of the effects of single doses of morphine and thebaine on body temperature, activity, and brain and heart levels of catecholamines and serotonin.

Authors: J W SLOAN; J W BROOKS; A J EISENMAN; W R MARTIN
Journal: Psychopharmacologia Date: 1962-10-05

5. Behavioural and pharmacological studies on morphine-induced excitation of rats. Possible relation to brain catecholamines.

Authors: I H Ayhan; A Randrup
Journal: Psychopharmacologia Date: 1973

6. Time-dose relationships for locomotor activity effects of morphine after acute or repeated treatment.

Authors: M Babbini; W M Davis
Journal: Br J Pharmacol Date: 1972-10 Impact factor: 8.739

7. Monkey motor stimulation and altered social behavior during chronic methadone administration.

Authors: T J Crowley; M Hydinger; A J Stynes; A Feiger
Journal: Psychopharmacologia Date: 1975-08-21

8. Amphetamine and morphine may produce acute-withdrawal related hypoactivity by initially activating a common dopamine pathway.

Authors: Wesley White; Ilsun M White
Journal: Physiol Behav Date: 2016-07-25

9. Morphine dependence and dopaminergic activity: tests of circling responses in rats with unilateral nigral lesions.

Authors: J V Halliwell; R Kumar
Journal: Br J Pharmacol Date: 1980-12 Impact factor: 8.739

10. Stimulation of food intake following opiate agonists in rats but not hamsters.

Authors: M T Lowy; G K Yim
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530

Disturbed patterns of behaviour in morphine tolerant and abstinent rats.

1. TOLERANCE TO AND PHYSICAL DEPENDENCE ON MORPHINE IN RATS.

2. RELATIONSHIP BETWEEN WATER AND FOOD INGESTION IN THE RAT.

3. Comparison of the effects of single doses of morphine and thebaine on body temperature, activity, and brain and heart levels of catecholamines and serotonin.

4. The addiction cycle to narcotics in the rat and its relation to catecholamines.

5. Effects of morphine on behavior maintained by four simple food-reinforcement schedules.

6. Preferences for morphine in rats: validation of an experimental model of dependence.

7. Long-term isolation in rats reduces morphine response.

8. Fighting of rats during post-morphine withdrawal: effect of prewithdrawal dosage.

9. Feeding and self-stimulation.

10. Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats.

1. Sexual behaviour of morphine-dependent and abstinent male rats.

2. Tolerance to the stimulant effects of morphine and pentazocine on avoidance responding in the rat.

3. Interaction between morphine and reinforcing lateral hypothalamic stimulation.