| Literature DB >> 5104178 |
A B Young, C D Pert, D G Brown, K M Taylor, S H Snyder.
Abstract
The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.Entities:
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Year: 1971 PMID： 5104178 DOI： 10.1126/science.173.3993.247
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728