Literature DB >> 5076198

The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver.

M R Rao, K Malathi, G Padmanaban.   

Abstract

The porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction of delta-aminolaevulinate synthetase and the consequent overproduction of haem. The allylisopropylacetamide-mediated breakdown of cytochrome P-450 is a rapid event and has a reciprocal relationship to the pattern of delta-aminolaevulinate synthetase induction. Breakdown of cytochrome P-450 appears to be one of the conditions leading to the ;derepression' of delta-aminolaevulinate synthetase.

Entities:  

Mesh：

Substances：

Year:  1972        PMID： 5076198      PMCID： PMC1178697          DOI： 10.1042/bj1270553

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Experimental porphyria. IV. Studies of liver catalase and other heme enzymes in sedormid porphyria.

Authors:  R SCHMID; J F FIGEN; S SCHWARTZ
Journal:  J Biol Chem       Date:  1955-11       Impact factor: 5.157

3.  Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations.

Authors:  J Baron; T R Tephly
Journal:  Arch Biochem Biophys       Date:  1970-08       Impact factor: 4.013

4.  The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene.

Authors:  J Baron; T R Tephly
Journal:  Biochem Biophys Res Commun       Date:  1969-08-15       Impact factor: 3.575

5.  Induction of -aminolevulinic acid synthetase in chick embryo liver cells in cluture.

Authors:  S Sassa; S Granick
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

6.  Behavior of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver.

Authors:  O Wada; Y Yano; G Urata; K Nakao
Journal:  Biochem Pharmacol       Date:  1968-04       Impact factor: 5.858

Review 7.  Disturbances of liver porphyrin metabolism caused by drugs.

Authors:  F de Matteis
Journal:  Pharmacol Rev       Date:  1967-12       Impact factor: 25.468

8.  Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.

Authors:  F De Matteis
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

9.  Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide.

Authors:  S A Landaw; E W Callahan; R Schmid
Journal:  J Clin Invest       Date:  1970-05       Impact factor: 14.808

10.  Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites.

Authors:  S Granick; A Kappas
Journal:  Proc Natl Acad Sci U S A       Date:  1967-05       Impact factor: 11.205
View more
  7 in total

1.  The effects of acetate, metal cations, phenobarbitone, porphyrogens and substrates of glycine acyltransferase on the utilization of haem by rat liver apo-(tryptophan pyrrolase).

Authors:  A A Badawy
Journal:  Biochem J       Date:  1977-05-15       Impact factor: 3.857

2.  The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857

3.  A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver.

Authors:  G Padmanaban; M R Rao; K Malathi
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

4.  Biochemical effects of the porphyrinogenic drug allylisopropylacetamide. A comparative study with phenobarbital.

Authors:  M R Rao; G Padmanaban
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

5.  Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide.

Authors:  A A Badawy; C J Morgan
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

6.  Tryptophan pyrrolase, the regulatory free haem and hepatic porphyrias. Early depletion of haem by clinical and experimental exacerbators of porphyria.

Authors:  A A Badawy
Journal:  Biochem J       Date:  1978-06-15       Impact factor: 3.857

7.  The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1973-12       Impact factor: 3.857
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.