Literature DB >> 4149247

The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.

A A Badawy, M Evans.   

Abstract

Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.

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Year:  1973        PMID： 4149247      PMCID： PMC1165861          DOI： 10.1042/bj1350555

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  A microsomal iron-porphyrin activator of rat liver tryptophan pyrrolase.

Authors:  P FEIGELSON; O GREENGARD
Journal:  J Biol Chem       Date:  1961-01       Impact factor: 5.157

2.  Effect of chronic intake of ethanol on pyridine nucleotide levels in rat liver and kidney.

Authors:  H Kalant; J M Khanna; J Loth
Journal:  Can J Physiol Pharmacol       Date:  1970-08       Impact factor: 2.273

3.  A comparison of mouse and rat liver enzymes and their response to treatment with various compounds.

Authors:  D A McIntosh; J C Topham
Journal:  Biochem Pharmacol       Date:  1972-04-01       Impact factor: 5.858

4.  Feedback control of rat liver tryptophan pyrrolase. I. End product inhibition of trytophan pyrrolase activity.

Authors:  Y S Cho-Chung; H C Pitot
Journal:  J Biol Chem       Date:  1967-03-25       Impact factor: 5.157

5.  Changes in liver tryptophan and tryptophan pyrrolase activity after administration of salicylate and tryptophan to the rat.

Authors:  A A Badawy; M J Smith
Journal:  Biochem Pharmacol       Date:  1972-01       Impact factor: 5.858

6.  The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo(3,4-d)pyrimidine (Allopurinol).

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1973-07       Impact factor: 3.857

7.  The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver.

Authors:  M R Rao; K Malathi; G Padmanaban
Journal:  Biochem J       Date:  1972-04       Impact factor: 3.857

8.  The effects of salicylate on the activity of rat liver tryptophan pyrrolase in vitro and in vivo.

Authors:  A A Badawy; M J Smith
Journal:  Biochem J       Date:  1971-06       Impact factor: 3.857
  8 in total
  4 in total

1.  The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

2.  The role of liver tryptophan pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism.

Authors:  A A Badawy; N F Punjani; M Evans
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857

3.  Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide.

Authors:  A A Badawy; C J Morgan
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

4.  Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.

Authors:  Abdulla A-B Badawy
Journal:  Biosci Rep       Date:  2021-07-30       Impact factor: 3.840
  4 in total

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