Literature DB >> 5069767

Utilization of operational schemes for analog synthesis in drug design.

J G Topliss.   

Abstract

Mesh：

Substances：

Year:  1972        PMID： 5069767     DOI： 10.1021/jm00280a002

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  50 in total

1.  Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Authors:  Zhenfu Han; Jerome S Pinkner; Bradley Ford; Robert Obermann; William Nolan; Scott A Wildman; Doug Hobbs; Tom Ellenberger; Corinne K Cusumano; Scott J Hultgren; James W Janetka
Journal:  J Med Chem       Date:  2010-06-24       Impact factor: 7.446

2.  Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor.

Authors:  Kana Shintani; Haruna Ebisu; Minagi Mukaiyama; Taisei Hatanaka; Takumi Chinen; Daisuke Takao; Yoko Nagumo; Akira Sakakura; Ichiro Hayakawa; Takeo Usui
Journal:  ACS Med Chem Lett       Date:  2020-03-30       Impact factor: 4.345

3.  Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs.

Authors:  Serena M Mershon; Allyson L Anding; Jason S Chapman; Margaret Clagett-Dame; Laura A Stonerock; Robert W Curley
Journal:  Bioorg Med Chem Lett       Date:  2006-10-25       Impact factor: 2.823

4.  QSAR modeling: where have you been? Where are you going to?

Authors:  Artem Cherkasov; Eugene N Muratov; Denis Fourches; Alexandre Varnek; Igor I Baskin; Mark Cronin; John Dearden; Paola Gramatica; Yvonne C Martin; Roberto Todeschini; Viviana Consonni; Victor E Kuz'min; Richard Cramer; Romualdo Benigni; Chihae Yang; James Rathman; Lothar Terfloth; Johann Gasteiger; Ann Richard; Alexander Tropsha
Journal:  J Med Chem       Date:  2014-01-06       Impact factor: 7.446

5.  Structural pairwise comparisons of HLM stability of phenyl derivatives: Introduction of the Pfizer metabolism index (PMI) and metabolism-lipophilicity efficiency (MLE).

Authors:  Mark L Lewis; Lourdes Cucurull-Sanchez
Journal:  J Comput Aided Mol Des       Date:  2008-09-18       Impact factor: 3.686

6.  The influence of hydrogen bonding on partition coefficients.

Authors:  Nádia Melo Borges; Peter W Kenny; Carlos A Montanari; Igor M Prokopczyk; Jean F R Ribeiro; Josmar R Rocha; Geraldo Rodrigues Sartori
Journal:  J Comput Aided Mol Des       Date:  2017-01-04       Impact factor: 3.686

7.  Structure-activity relationships of benzoic acid derivatives as antifeedants for the pine weevil, Hylobius abietis.

Authors:  C Rikard Unelius; Göran Nordlander; Henrik Nordenhem; Claes Hellqvist; Sacha Legrand; Anna-Karin Borg-Karlson
Journal:  J Chem Ecol       Date:  2006-10       Impact factor: 2.626

8.  Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents.

Authors:  Benjamin J Josey; Elizabeth S Inks; Xuejun Wen; C James Chou
Journal:  J Med Chem       Date:  2013-01-30       Impact factor: 7.446

9.  Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

Authors:  Ramesh Gujjar; Alka Marwaha; Farah El Mazouni; John White; Karen L White; Sharon Creason; David M Shackleford; Jeffrey Baldwin; William N Charman; Frederick S Buckner; Susan Charman; Pradipsinh K Rathod; Margaret A Phillips
Journal:  J Med Chem       Date:  2009-04-09       Impact factor: 7.446

10.  Allosteric modulation of adenosine receptors.

Authors:  Anikó Göblyös; Ad P Ijzerman
Journal:  Purinergic Signal       Date:  2008-07-10       Impact factor: 3.765
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.