Literature DB >> 5069731

Effect of ornithine alpha ketoglutarate on disturbances of brain metabolism caused by high blood ammonia.

I M James, G Dorf, S Hall, H Michel, D Dojcinov, G Gravagne, L MacDonell.   

Abstract

The administration of ammonium salts to free ventilated dogs causes an increase in the anaerobic consumption of glucose. Prior and simultaneous administration of the drug ornithine alpha ketoglutarate not only attenuates the rise in blood ammonia but also favourably affects these changes in brain metabolism.

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Year:  1972        PMID： 5069731      PMCID： PMC1412286          DOI： 10.1136/gut.13.7.551

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  12 in total

1.  SIMPLE METHODS FOR THE DETERMINATION OF THE CONCENTRATIONS OF CARBON DIOXIDE AND OXYGEN IN BLOOD.

Authors:  R J LINDEN; J R LEDSOME; J NORMAN
Journal:  Br J Anaesth       Date:  1965-02       Impact factor: 9.166

2.  The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma.

Authors:  S P BESSMAN; A N BESSMAN
Journal:  J Clin Invest       Date:  1955-04       Impact factor: 14.808

3.  [Determination of ammonia in the blood (Automatic method using dialysis)].

Authors:  G DROPSY; J BOY
Journal:  Ann Biol Clin (Paris)       Date:  1961 Mar-Apr       Impact factor: 0.459

4.  Ammonia toxicity and cerebral oxidative metabolism.

Authors:  G M MCKHANN; D B TOWER
Journal:  Am J Physiol       Date:  1961-03

5.  Cerebral metabolism in hepatic insufficiency.

Authors:  R W ALMAN; W R EHRMANTRAUT; J F FAZEKAS; H E TICKTIN
Journal:  Am J Med       Date:  1956-12       Impact factor: 4.965

6.  Effect of induced metabolic alkalosis in hepatic encephalopathy.

Authors:  I M James; D Sampson; S Nashat; H S Williams; M Garassini
Journal:  Lancet       Date:  1969-11-22       Impact factor: 79.321

7.  The effect of ammonium salts on cerebral and hind-limb consumption of oxygen and glucose in the ventilated dog.

Authors:  I M James; M Garassini; E Larbi
Journal:  Clin Sci       Date:  1971-11       Impact factor: 6.124

8.  Forearm metabolism in patients with chronic liver disease.

Authors:  G A Klassen; A Aronoff; G Karpati
Journal:  Clin Sci       Date:  1969-10       Impact factor: 6.124

9.  [Action of ornighine alpha-ketoglutarate on hyperammoniemia in the cirrhotic patient].

Authors:  H Michel; P Ogé; L Bertrand
Journal:  Presse Med       Date:  1971-04-17       Impact factor: 1.228

10.  Cerebral blood flow and metabolism in hepatic cirrhosis before and after portacaval shunt operation.

Authors:  G Bianchi Porro; A T Maiolo; P Della Porta
Journal:  Gut       Date:  1969-11       Impact factor: 23.059
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  1 in total

1.  Effect of ornithine alpha oxoglutarate on brain metabolism in patients with chronic liver disease.

Authors:  I M James; A N Hamlyn; P C Brant; P Hildrew
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-03       Impact factor: 10.154
  1 in total

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