Literature DB >> 5058730

Hyperlactataemia in phenformin-treated diabetics.

S K Varma, S J Heaney, W G Whyte, R S Walker.   

Abstract

Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous glucose load this effect was exaggerated and the lactate/pyruvate ratio increased. Withdrawal of the drug led to normal blood lactate levels and a fall in the lactate/pyruvate ratio.

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Year:  1972        PMID： 5058730      PMCID： PMC1789220          DOI： 10.1136/bmj.1.5794.205

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  7 in total

1.  SITE-SPECIFIC UNCOUPLING AND INHIBITION OF ENERGY TRANSFER BY BIGUANIDES.

Authors:  G SCHAEFER
Journal:  Biochim Biophys Acta       Date:  1964-11-08

2.  Mode of action and side-effects of phenformin hydrochloride.

Authors:  R S WALKER; A L LINTON; W S THOMSON
Journal:  Br Med J       Date:  1960-11-26

3.  Respiratory inhibition and hypoglycemia by biguanides and decamethylenediguanidine.

Authors:  D F STEINER; R H WILLIAMS
Journal:  Biochim Biophys Acta       Date:  1958-11

4.  Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation.

Authors:  W E HUCKABEE
Journal:  J Clin Invest       Date:  1958-02       Impact factor: 14.808

5.  Fatal lactic acidosis after an overdose of phenformin.

Authors:  D W Proctor; J M Stowers
Journal:  Br Med J       Date:  1967-10-28

6.  Lactic acidosis.

Authors:  R E Tranquada; W J Grant; C R Peterson
Journal:  Arch Intern Med       Date:  1966-02

7.  Lactic acidosis and phenformin.

Authors:  H K Johnson; C Waterhouse
Journal:  Arch Intern Med       Date:  1968-10
  7 in total
  6 in total

1.  Metabolic effects of fenfluramine in obese diabetics.

Authors:  S Larsen; L Vejtorp; P Hornnes; H Bechgaard; L Sestoft; J Lyngsoe
Journal:  Br J Clin Pharmacol       Date:  1977-10       Impact factor: 4.335

2.  Biguanides.

Authors:  M Nattrass; K G Alberti
Journal:  Diabetologia       Date:  1978-02       Impact factor: 10.122

3.  Metabolic abnormalities during combined sulphonylurea and phenformin therapy in maturity-onset diabetics.

Authors:  M Nattrass; P G Todd; D Turnell; K G Alberti
Journal:  Diabetologia       Date:  1978-06       Impact factor: 10.122

4.  The effects of diabetes mellitus, exercise, and single doses of biguanides upon lactate metabolism in man.

Authors:  P Fletcher; M R Hirji; S Kuhn; L Alexander; J C Mucklow
Journal:  Br J Clin Pharmacol       Date:  1986-06       Impact factor: 4.335

5.  Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.

Authors:  M Nattrass; P G Todd; L Hinks; B Lloyd; K G Alberti
Journal:  Diabetologia       Date:  1977-04       Impact factor: 10.122

6.  Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas.

Authors:  A K Waters; D B Morgan; J K Wales
Journal:  Diabetologia       Date:  1978-02       Impact factor: 10.122
  6 in total

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