Literature DB >> 334212

Metabolic effects of fenfluramine in obese diabetics.

S Larsen, L Vejtorp, P Hornnes, H Bechgaard, L Sestoft, J Lyngsoe.   

Abstract

1 In a single-blind, cross-over study fenfluramine in a daily dose of 120 mg was found to reduce the daily blood glucose level moderately in hospitalized obese diabetics treated with a 1200 calorie diabetic diet. 2 After 7 days of treatment, fenfluramine was found not to influence the intravenous glucose tolerance, the insulin response to intravenously administered glucose, or the growth hormone response to arginine. 3 No changes in blood levels of lactate, beta hydroxybutyrate, triglycerides or cholesterol were seen during fenfluramine treatment.

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Year:  1977        PMID: 334212      PMCID: PMC1429146          DOI: 10.1111/j.1365-2125.1977.tb00781.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  16 in total

1.  [ENZYMATIC DETERMINATION OF KETONE BODIES IN BLOOD].

Authors:  H U BERGMEYER; E BERNT
Journal:  Enzymol Biol Clin (Basel)       Date:  1965

2.  Effect of oral antidiabetic drugs on blood-sugar and inorganic phosphate curves in oral and intravenous glucosetolerance tests.

Authors:  S E JENSEN; K LUNDBAEK; B MOLLER; O J RAFAELSEN
Journal:  Acta Med Scand       Date:  1958-01-31

3.  Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus.

Authors:  K LUNDBAEK
Journal:  Br Med J       Date:  1962-06-02

4.  Effect of fenfluramine on blood-lipids in man.

Authors:  G L Pawan
Journal:  Lancet       Date:  1969-03-08       Impact factor: 79.321

5.  Hypoglycemic action of fenfluramine in diabetes mellitus.

Authors:  J R Turtle; J A Burgess
Journal:  Diabetes       Date:  1973-11       Impact factor: 9.461

6.  The effect of a low-calorie diet with and without fenfluramine on the glucose tolerance and insulin secretion of obese maturity-onset diabetics.

Authors:  J R Dykes
Journal:  Postgrad Med J       Date:  1973-05       Impact factor: 2.401

7.  The effect of gastrin on basal- and glucose-stimulated insulin secretion in man.

Authors:  J F Rehfeld; F Stadil
Journal:  J Clin Invest       Date:  1973-06       Impact factor: 14.808

8.  [A new determination of the neutral fats in blood serum and tissue. II. Reliability of the method, other neutral fat determinations, normal values for triglycerides and glycerin in human blood].

Authors:  M Eggstein
Journal:  Klin Wochenschr       Date:  1966-03-01

9.  Hyperlactataemia in phenformin-treated diabetics.

Authors:  S K Varma; S J Heaney; W G Whyte; R S Walker
Journal:  Br Med J       Date:  1972-01-22

10.  Effect of fenfluramine on human growth hormone release.

Authors:  W R Sulaiman; R H Johnson
Journal:  Br Med J       Date:  1973-05-12
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