Literature DB >> 500499

Herquline, a new alkaloid produced by Penicillium herquei. Fermentation, isolation and properties.

S Omura, A Hirano, Y Iwai, R Masuma.   

Abstract

A new alkaloid named herquline has been isolated from culture broth of Penicillium herquei Fg-372 by solvent extraction and silica gel chromatography. The molecular formula of herquline has been determined as C19H26N2O2 on the basis of elemental analysis and its high resolution mass spectrometry. The compound does not possess antimicrobial activities, but weakly inhibits blood platelet aggregation induced by adenosine diphosphate.

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Year:  1979        PMID: 500499     DOI: 10.7164/antibiotics.32.786

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  6 in total

1.  Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.

Authors:  James P Cain; Alexander V Mayorov; Minying Cai; Hui Wang; Bahar Tan; Kevin Chandler; YeonSun Lee; Ravil R Petrov; Dev Trivedi; Victor J Hruby
Journal:  Bioorg Med Chem Lett       Date:  2006-08-22       Impact factor: 2.823

2.  Concise Total Synthesis of Herqulines B and C.

Authors:  Chi He; Thomas P Stratton; Phil S Baran
Journal:  J Am Chem Soc       Date:  2018-12-24       Impact factor: 15.419

Review 3.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

Review 4.  Philosophy of new drug discovery.

Authors:  S Omura
Journal:  Microbiol Rev       Date:  1986-09

5.  Pd(II)-catalyzed carbonylation of C(sp3)-H bonds: a new entry to 1,4-dicarbonyl compounds.

Authors:  Eun Jeong Yoo; Masayuki Wasa; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2010-11-17       Impact factor: 15.419

6.  Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A.

Authors:  Xia Yu; Fang Liu; Yi Zou; Man-Cheng Tang; Leibniz Hang; K N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2016-10-06       Impact factor: 15.419

  6 in total

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