Literature DB >> 499423

Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulating compound BM 12.531.

U Bicker, K D Friedberg, G Hebold, K Mengel.   

Abstract

BM 12.531, the 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, (prop. INN Azimexon), reduces significantly the acute toxicity of cyclophosphamide and X-rays in rats and mice, respectively. The leucopenia induced by X-rays was partially compensated by BM 12.531 in rats.

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Year:  1979        PMID： 499423     DOI： 10.1007/bf01964009

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  Carcinostatic action of 2-cyanaziridines against a sarcoma in rats.

Authors:  U Bicker; P Fuhse
Journal:  Exp Pathol (Jena)       Date:  1975

2.  A simplified method of evaluating dose-effect experiments.

Authors:  J T LITCHFIELD; F WILCOXON
Journal:  J Pharmacol Exp Ther       Date:  1949-06       Impact factor: 4.030

3.  N-(2-cyanethylene-)urea--an asparagine analogous cytostatic compound?

Authors:  U Bicker
Journal:  Exp Pathol (Jena)       Date:  1975

4.  Immunomodulating effects of BM 12.531 in animals and tolerance in man.

Authors:  U Bicker
Journal:  Cancer Treat Rep       Date:  1978-11

5.  Investigations in mice on the potentiation of resistance to infections by a new immunostimulant compound.

Authors:  U Bicker; A E Ziegler; G Hebold
Journal:  J Infect Dis       Date:  1979-04       Impact factor: 5.226

6.  Animal experiments on the compensation of the immunosuppressive action of cyclophosphamide by 2-[-2-cyanaziridinyl-(1)-]-2-[-2-carbamoylaziridinyl-(1)]-propane BM 12 531.

Authors:  U Bicker; G Hebold; A E Ziegler; W Maus
Journal:  Exp Pathol (Jena)       Date:  1978
  6 in total
  2 in total

1.  The action of azimexone on the cells of the hemopoietic system in mice, especially after damage with X-rays.

Authors:  K D Friedberg; K Mengel; E Schlick
Journal:  Radiat Environ Biophys       Date:  1983       Impact factor: 1.925

2.  Effect of azimexon (BM 12.531) on mouse granulocyte-macrophage and monocyte-macrophage progenitor cells.

Authors:  J C Jeng; K F McCarthy; M A Chirigos; J F Weiss
Journal:  Experientia       Date:  1982-01-15
  2 in total

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