Literature DB >> 7056357

Effect of azimexon (BM 12.531) on mouse granulocyte-macrophage and monocyte-macrophage progenitor cells.

J C Jeng, K F McCarthy, M A Chirigos, J F Weiss.   

Abstract

Treatment of mice with 25 mg/kg azimexon (BM 12.531) resulted in an increase ln granulocyte-macrophage colony-forming cells (GM-CFC) in spleen and bone marrow after a transient depression in the cell populations. Bone marrow monocyte-macrophage colony-forming cells (MM-CFC) increased at 7 days after treatment, and splenic MM CFC were least affected by azimexon treatment. The increase in granulocytic and monocytic colony-forming cells may play a role in the previously reported protection by azimexon against radiation and drug-induced toxicity.

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Year:  1982        PMID： 7056357     DOI： 10.1007/bf01944571

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Effect of Myobacterium bovis (strain Bacillus Calmette-Guérin) on macrophage production by the bone marrow of tumor-bearing mice.

Authors:  B Fisher; S Taylor; M Levine; E Saffer; E R Fisher
Journal:  Cancer Res       Date:  1974-07       Impact factor: 12.701

2.  The effect of a single and repeated administration of Corynebacterium parvum on bone marrow macrophage colony production in normal mice.

Authors:  N Wolmark; M Levine; B Fisher
Journal:  J Reticuloendothel Soc       Date:  1974-10

3.  Factors from mouse tissues stimulating colony growth of mouse bone marrow cells in vitro.

Authors:  T R Bradley; E R Stanley; M A Sumner
Journal:  Aust J Exp Biol Med Sci       Date:  1971-12

4.  Controlling the production of blood cells.

Authors:  M J Cline; D W Golde
Journal:  Blood       Date:  1979-01       Impact factor: 22.113

5.  Detection of in vitro macrophage colony-forming cells (M-CFC) in mouse bone marrow, spleen, and peripheral blood.

Authors:  T J MacVittie; M Porvaznik
Journal:  J Cell Physiol       Date:  1978-12       Impact factor: 6.384

6.  Velocity sedimentation studies on monocyte-macrophage colony-forming cells from marrow, spleen, blood and peritoneal exudate.

Authors:  K F McCarthy; T J MacVittie
Journal:  J Reticuloendothel Soc       Date:  1978-09

7.  The immunomodulatory effect on BM 12.531 (azimexon) on normal or tumored mice: in vitro and in vivo studies.

Authors:  W A Stylos; M A Chirigos; V Papademetriou; L Lauer
Journal:  J Immunopharmacol       Date:  1980

8.  Immunomodulating effects of BM 12.531 in animals and tolerance in man.

Authors:  U Bicker
Journal:  Cancer Treat Rep       Date:  1978-11

9.  Comparative effects of Corynebacterium parvum, Brucella abortus extract, Bacillus Calmette-Guérin, glucan, levamisole, and tilorone with or without cyclophosphamide on tumor growth, macrophage production, and macrophage cytotoxicity in a murine mammary tumor model.

Authors:  B Fisher; M Gebhardt
Journal:  Cancer Treat Rep       Date:  1978-11

10.  Animal experiments on the compensation of the immunosuppressive action of cyclophosphamide by 2-[-2-cyanaziridinyl-(1)-]-2-[-2-carbamoylaziridinyl-(1)]-propane BM 12 531.

Authors:  U Bicker; G Hebold; A E Ziegler; W Maus
Journal:  Exp Pathol (Jena)       Date:  1978
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  1 in total

1.  The action of azimexone on the cells of the hemopoietic system in mice, especially after damage with X-rays.

Authors:  K D Friedberg; K Mengel; E Schlick
Journal:  Radiat Environ Biophys       Date:  1983       Impact factor: 1.925
  1 in total

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