Literature DB >> 4992015

6-(p-hydroxyphenylazo)-uracil: a selective inhibitor of host DNA replication in phage-infected Bacillus subtilis.

N C Brown.   

Abstract

The azopyrimidine, 6-(p-hydroxyphenylazo)-uracil, inhibits the replication of bacterial DNA selectively, completely, and reversibly, and has no apparent effects on the metabolism of other cellular macromolecules thus far examined. The mechanism of its action has been investigated in uninfected and phage-infected Bacillus subtilis, and the compound appears to be specific for a host function. In cells infected with virulent phage the synthesis of phage DNA proceeds normally, while residual host DNA synthesis is completely blocked. The drug-sensitive host site retains its sensitivity even after partial disruption of the cell by lysozyme treatment.

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Year:  1970        PMID： 4992015      PMCID： PMC283373          DOI： 10.1073/pnas.67.3.1454

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  THE POSSIBLE ROLE OF RECOMBINATION IN THE INFECTION OF COMPETENT BACILLUS SUBTILIS BY BACTERIOPHAGE DEOXYRIBONUCLEIC ACID.

Authors:  S OKUBO; B STRAUSS; M STODOLSKY
Journal:  Virology       Date:  1964-12       Impact factor: 3.616

2.  TRANSFORMABLE THYMINE-REQUIRING MUTANT OF BACILLUS SUBTILS.

Authors:  J L FARMER; F ROTHMAN
Journal:  J Bacteriol       Date:  1965-01       Impact factor: 3.490

3.  A simple membrane fractionation method for determining the distribution of radioactivity in chemical fractions of Bacillus cereus.

Authors:  D B ROODYN; H G MANDEL
Journal:  Biochim Biophys Acta       Date:  1960-06-17

4.  Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli.

Authors:  I R LEHMAN; M J BESSMAN; E S SIMMS; A KORNBERG
Journal:  J Biol Chem       Date:  1958-07       Impact factor: 5.157

5.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

6.  DNA synthesis in vitro.

Authors:  D W Smith; H E Schaller; F J Bonhoeffer
Journal:  Nature       Date:  1970-05-23       Impact factor: 49.962

7.  Interaction of rifamycin with bacterial RNA polymerase.

Authors:  W Wehrli; F Knüsel; K Schmid; M Staehelin
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

8.  Formation of covalent circles of lambda DNA by E. coli extracts.

Authors:  M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  1967-01       Impact factor: 11.205

9.  Host macromolecular synthesis in bacteriophage-infected Bacillus subtilis.

Authors:  J J Pène
Journal:  Bacteriol Rev       Date:  1968-12

10.  Bactericidal action of nalidixic acid on Bacillus subtilis.

Authors:  T M Cook; K G Brown; J V Boyle; W A Goss
Journal:  J Bacteriol       Date:  1966-11       Impact factor: 3.490
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  67 in total

1.  Disclosing the in vivo organization of a viral histone-like protein in Bacillus subtilis mediated by its capacity to recognize the viral genome.

Authors:  Isabel Holguera; David Ballesteros-Plaza; Daniel Muñoz-Espín; Margarita Salas
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

2.  RefZ facilitates the switch from medial to polar division during spore formation in Bacillus subtilis.

Authors:  Jennifer K Wagner-Herman; Remi Bernard; Roisin Dunne; Alexandre W Bisson-Filho; Krithika Kumar; Trang Nguyen; Lawrence Mulcahy; John Koullias; Frederico J Gueiros-Filho; David Z Rudner
Journal:  J Bacteriol       Date:  2012-06-22       Impact factor: 3.490

3.  Primosomal proteins DnaD and DnaB are recruited to chromosomal regions bound by DnaA in Bacillus subtilis.

Authors:  Wiep Klaas Smits; Houra Merrikh; Carla Yaneth Bonilla; Alan D Grossman
Journal:  J Bacteriol       Date:  2010-11-19       Impact factor: 3.490

4.  DNA Synthesis and Gene Expression in Bacillus subtilis Infected with Wild-Type and Hypermodification-Defective Bacteriophage SP10.

Authors:  H Witmer; M Franks
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103

5.  Nutritional control of elongation of DNA replication by (p)ppGpp.

Authors:  Jue D Wang; Glenn M Sanders; Alan D Grossman
Journal:  Cell       Date:  2007-03-09       Impact factor: 41.582

6.  Dynamic association of the replication initiator and transcription factor DnaA with the Bacillus subtilis chromosome during replication stress.

Authors:  Adam M Breier; Alan D Grossman
Journal:  J Bacteriol       Date:  2008-11-14       Impact factor: 3.490

7.  Mechanism of the Heat Sensitization of Bacillus subtilis Spores by Ethidium Bromide.

Authors:  J H Hanlin; R A Slepecky
Journal:  Appl Environ Microbiol       Date:  1985-06       Impact factor: 4.792

8.  Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile.

Authors:  Erika van Eijk; Ilse M Boekhoud; Ed J Kuijper; Ingrid M J G Bos-Sanders; George Wright; Wiep Klaas Smits
Journal:  Antimicrob Agents Chemother       Date:  2019-01-29       Impact factor: 5.191

9.  Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo.

Authors:  Wiep Klaas Smits; Alexi I Goranov; Alan D Grossman
Journal:  Mol Microbiol       Date:  2009-12-04       Impact factor: 3.501

10.  6(p-Hydroxyphenylazo)-uracil: a reversible, selective inhibitor of the replication of deoxyribonucleic acid of staphylococcal bacteriophage P11-M15.

Authors:  N C Brown
Journal:  J Virol       Date:  1971-11       Impact factor: 5.103
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