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Literature DB >> 4987629

Directional character of proton transfer in enzyme catalysis.

Abstract

Hydrogen bonding can facilitate proton transfer in certain directions and retard proton transfer in certain other directions. By assuming that directed proton transfer along strategically oriented hydrogen bonds in the enzyme-substrate complex plays an important role in determining the efficiency and specificity of the enzyme, we present a unified interpretation for the reported observations on carbonic anhydrase and alpha-chymotrypsin.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1970 PMID： 4987629 PMCID： PMC283132 DOI： 10.1073/pnas.66.3.874

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. Phosphopeptides from acid-hydrolyzed P32-labeled diisopropylphosphoryl chymotrypsin.

Authors: N K SCHAFFER; L SIMET; S HARSHMAN; R R ENGLE; R W DRISKO
Journal: J Biol Chem Date: 1957-03 Impact factor: 5.157

2. Proposed mechanism of action of hydrolytic enzymes.

Authors: L W CUNNINGHAM
Journal: Science Date: 1957-06-07 Impact factor: 47.728

3. Isolation of acetyl peptides from acetylchymotrypsin.

Authors: R A OOSTERBAAN; M E VAN ADRICHEM
Journal: Biochim Biophys Acta Date: 1958-02

4. THE MECHANISM OF CHYMOTRYPSIN-CATALYZED REACTIONS.

Authors: H Gutfreund; J M Sturtevant
Journal: Proc Natl Acad Sci U S A Date: 1956-10 Impact factor: 11.205

5. Catalytic action of the metal peptidases.

Authors: E L SMITH
Journal: Fed Proc Date: 1949-09

6. Crystallographic studies of the activity of hen egg-white lysozyme.

Authors: C C Blake; L N Johnson; G A Mair; A C North; D C Phillips; V R Sarma
Journal: Proc R Soc Lond B Biol Sci Date: 1967-04-18

7. Action of pepsin on cationic synthetic substrates.

Authors: T R Hollands; I M Voynick; J S Fruton
Journal: Biochemistry Date: 1969-02 Impact factor: 3.162

8. Role of a buried acid group in the mechanism of action of chymotrypsin.

Authors: D M Blow; J J Birktoft; B S Hartley
Journal: Nature Date: 1969-01-25 Impact factor: 49.962

9. An electrophilic mechanism in the chymotrypsin-catalyzed hydrolysis of anilide substrates.

Authors: T Inagami; S S York; A Patchornik
Journal: J Am Chem Soc Date: 1965-01-05 Impact factor: 15.419

10. On the elucidation of the pH dependence of chymotrypsin catalyzed reactions at alkaline pH.

Authors: A Himoe; G P Hess
Journal: Biochem Biophys Res Commun Date: 1966-05-03 Impact factor: 3.575

5 in total

1. alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities.

Authors: Kristin Coffman Haddad; James L Sudmeier; Daniel A Bachovchin; William W Bachovchin
Journal: Proc Natl Acad Sci U S A Date: 2005-01-18 Impact factor: 11.205

2. 13-C nuclear magnetic resonance studies on the mechanism of action of carbonic anhydrase.

Authors: P L Yeagle; C H Lochmüller; R W Henkens
Journal: Proc Natl Acad Sci U S A Date: 1975-02 Impact factor: 11.205

3. Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.

Authors: E L Ash; J L Sudmeier; R M Day; M Vincent; E V Torchilin; K C Haddad; E M Bradshaw; D G Sanford; W W Bachovchin
Journal: Proc Natl Acad Sci U S A Date: 2000-09-12 Impact factor: 11.205

4. Structure of a serine protease poised to resynthesize a peptide bond.

Authors: Elena Zakharova; Martin P Horvath; David P Goldenberg
Journal: Proc Natl Acad Sci U S A Date: 2009-06-19 Impact factor: 11.205

5. Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase.

Authors: Elena O Levina; Maria G Khrenova; Andrey A Astakhov; Vladimir G Tsirelson
Journal: RSC Adv Date: 2020-02-27 Impact factor: 4.036

5 in total