Literature DB >> 498358

Isolation and structure determination of enzymatically formed styrene oxide glutathione conjugates.

J Pachecka, P Gariboldi, L Cantoni, G Belvedere, E Mussini, M Salmona.   

Abstract

When styrene oxide was incubated with glutathione in the presence of rat liver cytosolic fraction, two conjugates were formed. Structural investigation by mass spectrometry (MS), proton magnetic resonance (PMR) analysis and chemical fragmentation showed the presence of two positional isomers, namely S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in a ratio of approx. 60 : 40.

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Year:  1979        PMID: 498358     DOI: 10.1016/0009-2797(79)90134-0

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN: 0009-2797            Impact factor:   5.192


  2 in total

1.  Detection of protein adduction derived from styrene oxide to cysteine residues by alkaline permethylation.

Authors:  Jieyu Dai; Fan Zhang; Jiang Zheng
Journal:  Anal Biochem       Date:  2010-05-06       Impact factor: 3.365

2.  Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats.

Authors:  E Elovaara; H Vainio; A Aitio
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

  2 in total

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