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Literature DB >> 4980063

Isolation of an antigen of Neisseria gonorrhoeae involved in the human immune response to gonococcal infection.

J D Schmale, D G Danielsson, J F Smith, L Lee, W L Peacock.

Abstract

Ion-exchange chromatography was used to isolate a fraction from disrupted gonococci which reacts with sera from patients with gonococcal disease in complement-fixation and gel-diffusion tests. This antigenic fraction was shown to be the same as that previously described as having been isolated by gel filtration. The method reported here has the advantage of greater rapidity of isolation together with some improvement in purity.

Entities: Disease Species

Mesh：

Substances：
Antigens

Year: 1969 PMID： 4980063 PMCID： PMC250040 DOI： 10.1128/jb.99.2.469-471.1969

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

2 in total

1. Preparation of cell walls and protoplasm of Neisseria with the Ribi cell fractionator.

Authors: J E Martin; W L Peacock; G Reising; D S Kellogg; E Ribi; J D Thayer
Journal: J Bacteriol Date: 1969-03 Impact factor: 3.490

2. Antigens of Neisseria gonorrhoeae: characterization by gel filtration, complement fixation, and agar-gel diffusion of antigens of gonococcal protoplasm.

Authors: D G Danielsson; J D Schmale; W L Peacock; J D Thayer
Journal: J Bacteriol Date: 1969-03 Impact factor: 3.490

2 in total

11 in total

Isolation of an antigen of Neisseria gonorrhoeae involved in the human immune response to gonococcal infection.

1. Preparation of cell walls and protoplasm of Neisseria with the Ribi cell fractionator.

2. Antigens of Neisseria gonorrhoeae: characterization by gel filtration, complement fixation, and agar-gel diffusion of antigens of gonococcal protoplasm.

1. Particulate Fractions of Neisseria gonorrhoeae.

2. Serological tests for gonorrhoea.

3. A comparison of serological tests for the diagnosis of gonorrhoea.

4. Gonococcal infections. Laboratory, clinical and epidemiological aspects.

5. Antigenic analysis of Neisseria gonorrhoeae by crossed immunoelectrophoresis.

6. Purification of Neisseria gonorrhoeae surface L-antigen.

7. Human antibody response to lipopolysaccharides from Neisseria gonorrhoeae.

8. Quantitative determination of antibody to gonococcal pili. Changes in antibody levels with gonococcal infection.

9. Transformation of lymphocytes in gonorrhea before and after therapy.

10. Identification of a gonococcal antigen important in the human immune response.